AUTOMATED METHOD FOR ASSESSMENT OF TUMOR RESPONSE TO THERAPY WITH MULTI-PARAMETRIC MRI
First Claim
1. A method for assessing a tumor'"'"'s response to therapy, comprising:
- providing images of a first study of a patient and images of a second study of the patient, the second study occurring after the first study and after the patient undergoes first therapy to treat a tumor, each study comprising first and second types of functional magnetic resonance (fMR) images;
performing a first registration in which the images within each study are registered such that all of the first and second types of fMR images are in a common frame of reference and anatomically aligned;
performing a second registration in which reference images from both studies are co-registered, wherein an operation resulting from the co-registration is applied to all images of the second study;
segmenting the tumor in an image of each of the second registered studies; and
determining that first and second fMR measure differences exist between the segmented tumor of the first study and the segmented tumor of the second study, the first fMR measure difference being obtained from the first type of fMR images, the second fMR measure difference being obtained from the second type of fMR images, the determination being enabled by the second registration.
3 Assignments
0 Petitions
Accused Products
Abstract
A method for assessing a tumor'"'"'s response to therapy, includes providing images of a first study of a patient and images of a second study of the patient, the second study occurring after the first study and after the patient undergoes therapy to treat a tumor, each study comprising first and second types of functional magnetic resonance (fMR) images, performing a first registration in which the images within each study are registered, performing a second registration in which reference images from both studies are co-registered, segmenting the tumor in an image of each of the second registered studies; and determining that first and second fMR measure differences exist between the segmented tumor'"'"'s of the first and second studies, the first fMR measure difference being obtained from the first type of fMR images, the second fMR measure difference being obtained from the second type of fMR images.
-
Citations
22 Claims
-
1. A method for assessing a tumor'"'"'s response to therapy, comprising:
-
providing images of a first study of a patient and images of a second study of the patient, the second study occurring after the first study and after the patient undergoes first therapy to treat a tumor, each study comprising first and second types of functional magnetic resonance (fMR) images; performing a first registration in which the images within each study are registered such that all of the first and second types of fMR images are in a common frame of reference and anatomically aligned; performing a second registration in which reference images from both studies are co-registered, wherein an operation resulting from the co-registration is applied to all images of the second study; segmenting the tumor in an image of each of the second registered studies; and determining that first and second fMR measure differences exist between the segmented tumor of the first study and the segmented tumor of the second study, the first fMR measure difference being obtained from the first type of fMR images, the second fMR measure difference being obtained from the second type of fMR images, the determination being enabled by the second registration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A system for assessing a tumor'"'"'s response to therapy, comprising:
-
a memory device for storing a program; a processor in communication with the memory device, the processor operative with the program to; receive images of a first study of a patient and images of a second study of the patient, the second study occurring after the first study and after the patient undergoes first therapy to treat a tumor, each study comprising first and second types of functional magnetic resonance (fMR) images; perform a first registration in which the images within each study are registered such that all of the first and second types of fMR images are in a common frame of reference and anatomically aligned; perform a second registration in which reference images from both studies are co-registered, wherein an operation resulting from the co-registration is applied to all images of the second study; segment the tumor in an image of each of the second registered studies; and determine that first and second fMR measure differences exist between the segmented tumor of the first study and the segmented tumor of the second study, the first fMR measure difference being obtained from the first type of fMR images, the second fMR measure difference being obtained from the second type of fMR images, the determination being enabled by the second registration. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
Specification