Systems and methods for skin rejuvenation

• US 20100255079A1
• Filed: 04/02/2010
• Published: 10/07/2010
• Est. Priority Date: 04/02/2009
• Status: Active Grant

• Current Assignee: PILI SIGLO XXI USA, LLC
• Original Assignee: Sesvalia Usa, LLC
• Inventors: Sanmiguel, Gabriel Serrano, Nuñez, Juan Manuel Serrano, Zamora, Joaquin Melendez
• Granted Patent: US 8,568,749 B2
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 2800/70 Biological properties of the composition as a whole
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/362 Polycarboxylic acids
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/4926 having six membered rings
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61N 1/40 : Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2005/0652 : Arrays of diodes
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/067 : using laser light
• CPC Class Codes: A61Q 17/00 : Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 : for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 : Washing or bathing preparations

Abstract

Systems and methods for skin rejuvenation are disclosed herein. In an embodiment, a skin rejuvenation system includes a unit dose of a booster product that includes active ingredients of ferulic acid and phloretin; a unit dose of at least one exfoliating product that includes active ingredients of ferulic acid and phloretin in combination with fruit acids or alpha hydroxyacids; and a unit dose of a nano-additive product for enhancing penetration of the active ingredients. A method for skin rejuvenation includes applying topically, to a skin surface to be treated, a booster product including active ingredients of ferulic acid and phloretin; applying topically, to the skin surface, at least one exfoliating product including active ingredients of ferulic acid and phloretin in combination with one of fruit acids or alpha hydroxyacids; and applying topically, to the skin surface, a nano-additive product for enhancing penetration of the active ingredients.

Claims

1. A system for skin rejuvenation comprising:

a booster product for activating a skin area to be treated, the booster product comprising active ingredients including ferulic acid and phloretin in a dermatologically acceptable carrier;

at least one exfoliating product for exfoliating the skin area, the exfoliating product comprising active ingredients including ferulic acid and phloretin in a dermatologically acceptable carrier; and

a nano-additive product for enhancing penetration of the booster product and the exfoliating product inside the skin area, the nano-additive product comprising active ingredients including ferulic acid and phloretin in liposomes.

2. The system of claim 1, wherein the booster product comprises about 12% ferulic acid and about 5% phloretin.

3. The system of claim 1, wherein the at least one exfoliating product comprises about 8% ferulic acid, about 5% phloretin, a mixture of about 5% alpha hydroxyacids, and from about 0.25% to about 0.50% retinol.

4. The system of claim 1, wherein the at least one exfoliating product comprises about 8% ferulic acid, about 5% phloretin, about 5% caffeic acid, about 5% rosmarinic acid, about 5% lactic acid, and from about 15% to about 20% trichloroacetic acid.

5. The system of claim 1, wherein the active ingredients in the nano-additive product further includes at least one of azelaic acid, nicotinic acid, retinol, and ceramides.

6. The system of claim 1, further comprising an oxygen product for increasing an oxygen content to the skin area.

7. The system of claim 1, further comprising a Vitamin C product for ameliorating symptoms associated with photo-aging of the skin area.

8. A skin rejuvenation kit comprising:

a unit dose of a booster product in a first container, the booster product comprising ferulic acid and phloretin in a mixture of ethanol and macrogol;

a unit dose of at least one exfoliating product in a second container, the exfoliating product comprising ferulic acid and phloretin in a mixture of ethanol and macrogol; and

a unit dose of a nano-additive product in a third container, the nano-additive product comprising ferulic acid and phloretin encapsulated in liposomes.

9. The kit of claim 8, wherein a concentration of ferulic acid in the booster product is about 12% and a concentration of ferulic acid in the exfoliating product is about 8%.

10. The kit of claim 8, wherein the exfoliating product further comprises fruit acids or alpha hydroxyacids.

11. The kit of claim 8, wherein the nano-additive product further comprises at least one of azelaic acid, nicotinic acid, retinol, and ceramides.

12. A method for skin rejuvenation comprising:

applying topically to a skin surface to be treated a booster product for activating the skin, the booster product comprising active ingredients including ferulic acid and phloretin in a dermatologically acceptable carrier;

applying topically to the skin surface at least one exfoliating product for exfoliating the skin, the exfoliating product comprising active ingredients including ferulic acid and phloretin in a dermatologically acceptable carrier; and

applying topically to the skin surface a nano-additive product for enhancing penetration of the booster product and the exfoliating product into the skin, the nano-additive product comprising active ingredients including ferulic acid and phloretin in liposomes.

13. The method of claim 12, wherein the booster product comprises about 12% ferulic acid and about 5% phloretin.

14. The method of claim 12, wherein the at least one exfoliating formulation comprises about 8% ferulic acid, about 5% phloretin, a mixture of about 5% alpha hydroxy acids, and from about 0.25% to about 0.50% retinol.

15. The method of claim 12, wherein the at least one exfoliating formulation comprises about 8% ferulic acid, about 5% phloretin, about 5% caffeic acid, about 5% rosmarinic acid, about 5% lactic acid, and from about 15% to about 20% trichloroacetic acid.

16. The method of claim 12, wherein the active ingredients in the nano-additive product further includes at least one of azelaic acid, nicotinic acid, retinol, and ceramides.

17. The method of claim 12, further comprising applying topically to the skin surface an oxygen product for increasing an oxygen content of the skin.

18. The method of claim 12, further comprising applying topically to the skin surface a Vitamin C product for ameliorating symptoms associated with photo-aging of the skin.

19. The method of claim 12, further comprising applying topically to the skin surface a protectant for protecting the skin from photo-damaging conditions.

20. The method of claim 12, further comprising performing a skin rejuvenation treatment on the skin surface, wherein the skin rejuvenation treatment is selected from the group consisting of intense pulsed light, light emitting diodes, laser therapy, light resurfacing therapy, radiofrequency, photodynamic therapy, dermabrasion, microdermabrasion, electroporation, iontophoresis, ultrasound, and combinations thereof.