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SUPRAMOLECULAR BIOCONJUGATES

  • US 20100255558A1
  • Filed: 05/05/2009
  • Published: 10/07/2010
  • Est. Priority Date: 01/31/1994
  • Status: Abandoned Application
First Claim
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1. A method for assembling a supramolecular bioconjugate comprising the steps of:

  • a) providing a first bioreactive complex said bioreactive complex comprising a first nucleic acid, said first nucleic acid attached to a first bioreactive agent, said first bioreactive agent comprising a first binding agent selected from the group consisting of protein A, an antibody, an Fc fragment, a Fab fragment, an antigen, a nucleic acid binding protein, and a cell adhesion molecule, wherein said first bioreactive agent is coupled to a molecule binding to said first bioreactive agent;

    b) providing at least a second bioreactive complex comprising at least two second nucleic acids, wherein one of the at least two second nucleic acids serves as a first mediator nucleic acid that comprises a nucleic acid sequence that is complementary to a sequence within said first nucleic acid, and wherein said at least two second nucleic acids are each attached to a second bioreactive agent, said second bioreactive agent comprising a second binding agent selected from the group consisting of protein A, an antibody, an Fc fragment, a Fab fragment, an antigen, a nucleic acid binding protein, and a cell adhesion molecule; and

    c) hybridizing in one step said complementary nucleic acids of said second bioreactive complex to said first nucleic acid of said first bioreactive complex to form a supramolecular bioconjugate, wherein at least one of the second bioreactive agent is selected to be able to react primarily with a desired bioreactive target, while part of the supramolecular bioconjugate.

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