SUPRAMOLECULAR NANOSTAMPING PRINTING DEVICE
First Claim
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1. A printing device for generating on a hydrogel substrate a complement image of a master having a first set of molecules bound to a surface of a first substrate comprising:
- a device for delivering a second hydrogel substrate comprising a cross-linked polymer to a surface of the master, wherein the hydrogel is capable of attachment to a second set of molecules that are reversibly attached to the first set of molecules bound to the first substrate, wherein the device provides conditions for dissociating the first and second set of molecules and stamping the second set of molecules on the cross-linked polymer strands of the second hydrogel substrate,and further wherein, the second set of molecules comprises a reactive functional group suitable for attaching to one or more attachment sites on the cross-linked polymer of the hydrogel, and a recognition component that allows the second set of molecules to reversibly bind to the first set of molecules.
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Abstract
A printing device for fabricating hydrogel based microarrays by a nanostamping process is provided. Features of a preferred printing device include: maintaing consistent temperature profile during contact; reproducible temperature profile during separation; constant and uniform pressure profile during contact; and parallelism tolerance during conditions where the gimbal is slightly offset.
69 Citations
7 Claims
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1. A printing device for generating on a hydrogel substrate a complement image of a master having a first set of molecules bound to a surface of a first substrate comprising:
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a device for delivering a second hydrogel substrate comprising a cross-linked polymer to a surface of the master, wherein the hydrogel is capable of attachment to a second set of molecules that are reversibly attached to the first set of molecules bound to the first substrate, wherein the device provides conditions for dissociating the first and second set of molecules and stamping the second set of molecules on the cross-linked polymer strands of the second hydrogel substrate, and further wherein, the second set of molecules comprises a reactive functional group suitable for attaching to one or more attachment sites on the cross-linked polymer of the hydrogel, and a recognition component that allows the second set of molecules to reversibly bind to the first set of molecules. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification