Metabolite Management System
First Claim
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1. A system for managing a metabolite in a body of a patient comprising:
- (a) a drug-delivery unit including a cannula configured for insertion into the body; and
(b) a metabolite-monitoring unit including a sampling probe configured for insertion into the body, said drug-delivery unit and said metabolite-monitoring unit being disposed in a housing such that said cannula and said sampling probe are in close proximity to each other thereby enabling their insertion into the body via one common skin perforation.
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Abstract
A metabolite monitoring system configured to deliver drugs and obtain metabolite samples via one common skin perforation and measure metabolite content by way of an optical measuring-cell having a primary flow-path of constant cross-sectional area.
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Citations
35 Claims
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1. A system for managing a metabolite in a body of a patient comprising:
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(a) a drug-delivery unit including a cannula configured for insertion into the body; and (b) a metabolite-monitoring unit including a sampling probe configured for insertion into the body, said drug-delivery unit and said metabolite-monitoring unit being disposed in a housing such that said cannula and said sampling probe are in close proximity to each other thereby enabling their insertion into the body via one common skin perforation. - View Dependent Claims (2, 3, 4, 5, 35)
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6. A method for managing a metabolite in a body of a patient comprising:
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(a) providing a combined drug delivery and metabolite measurement system having a cannula and a metabolite sampling probe disposed in close proximity to each other so as to enable their insertion into the body via one common skin perforation; and (b) inserting said cannula and said metabolite sampling probe into the body via one common skin perforation. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A method for managing a metabolite in a body of a patient comprising:
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(a) providing a combined drug delivery and metabolite measurement system; (b) delivering separate dosages of a drug to the patient, each of said dosages being separated by an interval of time; and (c) obtaining a metabolite sample from the patient after a minimum time delay following any one of said dosages sufficient for the metabolite sample to be indicative of an overall metabolite content in the body of the patient. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. An optical measuring-cell for use with a metabolite monitoring unit that employs an optical sensor with a light source deployed for illuminating a measurement region, the optical measuring-cell comprising:
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(a) a sheet of material having a groove defining a flow path passing through the measurement region illuminated by the light source, a portion of said groove within the measurement region being configured in a geometrical arrangement having a length at least 1.5 times greater than a maximum dimension of the measurement region; and (b) at least one sheet of transparent material bonded to said sheet of material so as to enclose said groove defining a flow path thereby ensuring sufficient liquid is exposed to said light source to facilitate accurate optical measurements. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. A layered, optical measuring-cell partially illuminated by a light source for a metabolite-monitoring unit comprising:
(a) a sheet of material having a groove defining an illuminated flow-path segment in fluid connection with a non-illuminated flow-path segment wherein a cross-sectional area of said illuminated flow-path segment substantially matches a cross-sectional area of said non-illuminated flow-path segment thereby facilitating uniform flow from said non-illuminated, flow-path segment to said illuminated, flow-path segment. - View Dependent Claims (29, 30, 31, 32, 33, 34)
Specification