Manufacturing execution systems (MES)

• US 20100256816A1
• Filed: 04/15/2010
• Published: 10/07/2010
• Est. Priority Date: 05/06/2004
• Status: Active Grant

• Current Assignee: SMP Logic Systems LLC
• Original Assignee: SMP Logic Systems LLC
• Inventors: Popp, Shane M.
• Granted Patent: US 8,491,839 B2
• Time in Patent Office: Days
• US Class Current: 700/268
• CPC Class Codes: G05B 19/41875 characterised by quality surveillance of production
• CPC Class Codes: G05B 2219/11 Plc I-O input output
• CPC Class Codes: G05B 2219/1112 Bit addressing, handling
• CPC Class Codes: G05B 2219/31277 Dispatching rules, shortest travel time or bidding based to reduce empty travel
• CPC Class Codes: G05B 2219/32177 Computer assisted quality surveyance, caq
• CPC Class Codes: G05B 2223/02 Indirect monitoring, e.g. monitoring production to detect faults of a system
• CPC Class Codes: G05B 23/0224 Process history based detection method, e.g. whereby history implies the availability of large amounts of data
• CPC Class Codes: G06Q 10/06 Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
• CPC Class Codes: G06Q 50/04 Manufacturing
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: Y02P 90/02 Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
• CPC Class Codes: Y02P 90/30 Computing systems specially adapted for manufacturing
• CPC Class Codes: Y02P 90/80 Management or planning
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

Manufacturing execution systems (MES) are disclosed herein. The MES and methods described herein provide an ability to control and monitor manufacturing processes (for example, chemical and pharmaceutical) and can ensure data and product integrity and ultimately minimize overall manufacturing cost.

Claims

1. ) An apparatus comprising,

a) an application software having a computer memory having computer executable instructions adapted for use in pharmaceutical manufacturing;

b) a plurality of devices used in pharmaceutical manufacturing using at least a mixing tank;

c) an input/output system; and

d) a controller

2. ) The apparatus of claim 1, wherein said input/output system is an analog to digital converter.

3. ) The apparatus of claim 1, wherein said controller is a display screen.

4. ) The apparatus of claim 1, wherein said device is a glycol system.

5. ) A method of monitoring an acceptance criteria of a glycol system said method comprising,

a) monitoring data generated by a glycol system during glycol manufacture;

b) maintaining the data over time to provide a historical record;

c) analyzing the historical record to provide a comparative analysis against an acceptance criteria;

d) taking corrective action during glycol manufacture to obviate a rejection against the acceptance criteria whereby said corrective action comprises modifying said glycol manufacture.

6. ) The method of claim 5, wherein the monitoring is part of a quality assurance protocol.

7. ) The method of claim 5, wherein the historical record consists of a time stamped audit trail.

8. ) The method of claim 5, wherein the glycol system uses at least a mixing tank.

9. ) The method of claim 5, wherein said monitoring is at initial process.

10. ) The method of claim 5, wherein said monitoring is at end process.

11. ) A method comprising,

a. deriving an algorithm implemented in computer executable instructions that performs analysis on data compiled from a glycol manufacturing process;

b. integrating said algorithm into a device used in a glycol manufacturing process whereby monitoring of the glycol manufacturing process is attained;

c. maintaining the data to provide a historic record of the glycol manufacturing process;

12. ) The method of claim 11, wherein said analysis is failure modes and effects analysis.

13. ) The method of claim 11, wherein the device is a mixing tank.

14. ) The method of claim 11, wherein the device is a modular cleanroom.

15. ) The method of claim 11, wherein the device is a pure water system.

16. ) The method of claim 11, wherein the monitoring occurs on a critical control point.

17. ) A computer memory having computer executable instructions which performs the method of claim 11.

18. ) A kit comprising the computer memory of claim 17.