LONGITUDINAL REGISTRATION OF ANATOMY IN MAGNETIC RESONANCE IMAGING
First Claim
Patent Images
1. A method for imaging a subject, comprising:
- correcting first and second images of a subject and registering the first image to the second image;
obtaining a deformation field that maps each element in the first image into a corresponding element in the second image by reducing a mapping error from the first image to the second image; and
calculating a volume of at least one region within the subject in the second image and using the deformation field to calculate a volume of the same at least one region within the subject in the first image.
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Abstract
Devices, systems, and techniques relate to detecting volumetric changes in imaged structures over time, including devices, systems and techniques that enable precise registration of structures (e.g., brain areas) after large or subtle deformations, allowing precise registration at small spatial scales with a low boundary contrast.
56 Citations
36 Claims
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1. A method for imaging a subject, comprising:
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correcting first and second images of a subject and registering the first image to the second image; obtaining a deformation field that maps each element in the first image into a corresponding element in the second image by reducing a mapping error from the first image to the second image; and calculating a volume of at least one region within the subject in the second image and using the deformation field to calculate a volume of the same at least one region within the subject in the first image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 32)
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27. A method for imaging an object, comprising:
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providing a function that represents a registration error between of a pair of images of an object; reducing the function to correct for at least one of relative intensity variation or relative structural deformation between the images; and producing a deformation field that registers one image of the pair to the other image of the pair. - View Dependent Claims (28, 29)
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30. A method for diagnosing or monitoring a progress of a pathology or a disease, comprising:
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correcting first and second images of a subject and registering the first image to the second image; obtaining a deformation field that maps each element in the first image into a corresponding element in the second image by minimizing, on a computer, a mapping error from the first image to the second image; calculating a volume of at least one region within the subject in the second image and using the deformation field to calculate a volume of the same at least one region within the subject in the first image; and quantifying a volumetric change in the first and second images of the region within the subject, in which the volumetric change at least in part determines a presence or a change in the pathology or the disease. - View Dependent Claims (31)
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33. A computer program product, encoded on a computer-readable medium, operable to cause a data processing apparatus to perform operations comprising:
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obtaining a first image of a subject and a second image of the subject, in which the first image is measured at a different time than the second image; correcting the first and second images; registering the first image to the second image; obtaining a deformation field that maps each element in the first image into a corresponding element in the second image by minimizing a function that represents a mapping error between the first and second images; and calculating a volume of at least one region within the subject in the second image and using the deformation field to calculate a volume of the same at least one region within the subject in the first image. - View Dependent Claims (34)
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35. A magnetic resonance imaging system comprising:
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a magnetic resonance system configured to provide a first image and a second image of a subject; and a data processing system configured to correct the first and second images; register the first image to the second image; obtain a deformation field that maps each element in the first image into a corresponding element in the second image by minimizing a function that represents a mapping error between the first and second images; and calculate a volume of at least one region within the subject in the second image and using the deformation field to calculate a volume of the same at least one region within the subject in the first image. - View Dependent Claims (36)
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Specification