Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film
First Claim
1. A method of imaging an ocular tear film, comprising:
- illuminating a region of interest of the ocular tear film with a multi-wavelength light source;
capturing optical wave interference of specularly reflected light including a background signal from the region of interest of the ocular tear film while illuminated by the multi-wavelength light source in at least one first image by an imaging device;
capturing the background signal from the region of interest of the ocular tear film in at least one second image by the imaging device; and
subtracting the at least one second image from the at least one first image to generate at least one resulting image containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced.
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Accused Products
Abstract
Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
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Citations
28 Claims
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1. A method of imaging an ocular tear film, comprising:
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illuminating a region of interest of the ocular tear film with a multi-wavelength light source; capturing optical wave interference of specularly reflected light including a background signal from the region of interest of the ocular tear film while illuminated by the multi-wavelength light source in at least one first image by an imaging device; capturing the background signal from the region of interest of the ocular tear film in at least one second image by the imaging device; and subtracting the at least one second image from the at least one first image to generate at least one resulting image containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification