KINETICS OF MOLECULAR RECOGNITION MEDIATED NANOPARTICLE SELF-ASSEMBLY
First Claim
Patent Images
1. A method of detecting a biomarker, comprising:
- coupling quantum dots to a molecular recognition element that binds to a biomarker of interest to form functionalized conjugates;
providing a sample from a subject;
introducing the sample and the functionalized conjugates to at least one sample holding channel in an incubation chamber to form agglomerates through self-assembly if contacted with the corresponding biomarker;
detecting the agglomerate by at least one of the rate of agglomeration and/or the number of agglomerates.
0 Assignments
0 Petitions
Accused Products
Abstract
A method of multiple protein biomarker detection, comprising providing at quantum dot-antibody conjugates that have an affinity for at least two different protein biomarkers; contacting the conjugates with a sample from a subject; allowing the proteins to bridge the antibodies, forming protein biomarker/quantum dot-antibody conjugate agglomerates; detecting the presence of the biomarkers by excitation of the agglomerates.
-
Citations
14 Claims
-
1. A method of detecting a biomarker, comprising:
-
coupling quantum dots to a molecular recognition element that binds to a biomarker of interest to form functionalized conjugates; providing a sample from a subject; introducing the sample and the functionalized conjugates to at least one sample holding channel in an incubation chamber to form agglomerates through self-assembly if contacted with the corresponding biomarker; detecting the agglomerate by at least one of the rate of agglomeration and/or the number of agglomerates. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
Specification