FUSION PROTEINS FOR DELIVERY OF ERYTHROPOIETIN TO THE CNS
First Claim
Patent Images
1. A composition comprising a neurotherapeutic peptide comprising a mature human erythropoietin (EPO) polypeptide covalently linked to a structure that is capable of crossing the blood brain barrier (BBB).
4 Assignments
0 Petitions
Accused Products
Abstract
The invention provides compositions, methods, and kits for increasing transport of a neurotrophin (e.g., erythropoietin (EPO)) across the blood brain barrier while allowing its activity to remain substantially intact. The neurotrophin (e.g., EPO) is transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems.
-
Citations
25 Claims
- 1. A composition comprising a neurotherapeutic peptide comprising a mature human erythropoietin (EPO) polypeptide covalently linked to a structure that is capable of crossing the blood brain barrier (BBB).
Specification