UTILIZATION OF MURAL THROMBUS FOR LOCAL DRUG DELIVERY INTO VASCULAR TISSUE
First Claim
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1. A method for stabilizing an extracellular matrix in a wall of a blood vessel comprising:
- advancing a delivery system to a treatment site positioned near a mural thrombus that covers at least a portion of the wall of the blood vessel;
advancing a delivery portion of the delivery device into the mural thrombus;
delivering a therapeutic agent through the delivery portion into the mural thrombus; and
allowing the agent to transport from the mural thrombus into the extracellular matrix of the vessel wall by diffusion to facilitate reduction of enzymatic degradation of protein in the extracellular matrix by the action of the agent.
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Abstract
The present disclosure is directed to methods and systems for stabilizing an extracellular matrix in a wall of a blood vessel. The method comprises delivering a therapeutic agent into mural thrombus, which covers the wall of the blood vessel. The agent is transported from the mural thrombus into the extracellular matrix of the vessel wall by diffusion. The agent then acts to reduce the enzymatic degradation of protein in the extracellular matrix.
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Citations
33 Claims
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1. A method for stabilizing an extracellular matrix in a wall of a blood vessel comprising:
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advancing a delivery system to a treatment site positioned near a mural thrombus that covers at least a portion of the wall of the blood vessel; advancing a delivery portion of the delivery device into the mural thrombus; delivering a therapeutic agent through the delivery portion into the mural thrombus; and allowing the agent to transport from the mural thrombus into the extracellular matrix of the vessel wall by diffusion to facilitate reduction of enzymatic degradation of protein in the extracellular matrix by the action of the agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for stabilizing an extracellular matrix layer in the vascular system of a body comprising:
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positioning a portion of a vascular catheter adjacent to or within a mural thrombus positioned adjacent to the extracellular matrix layer of a target region of the vascular system; and delivering a therapeutic agent in solution to the mural thrombus using the vascular catheter; and allowing the therapeutic agent to be transported to the extracellular matrix layer through the mural thrombus to promote the cross-linking protein in the extracellular matrix layer, thereby stabilizing the extracellular matrix. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A catheter system for the delivery of a therapeutic agent into a wall of a blood vessel, comprising:
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a delivery catheter, wherein the delivery catheter houses a therapeutic agent configured to promote the cross-linking of protein; and a delivery portion of the delivery catheter, wherein the delivery portion is configured to deliver the therapeutic agent from the delivery catheter into a mural thrombus. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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Specification