METHOD FOR DECREASING CARTILAGE DAMAGE IN DOGS

• US 20100261793A1
• Filed: 06/22/2010
• Published: 10/14/2010
• Est. Priority Date: 08/11/2003
• Status: Active Grant

• Current Assignee: Hill's Pet Nutrition Incorporated (Colgate-Palmolive Company)
• Original Assignee: Hill's Pet Nutrition Incorporated (Colgate-Palmolive Company)
• Inventors: Schoenherr, William David, Innes, John Francis, Jewell, Dennis Edward, Fritsch, Dale A., Little, Christopher Bond, Caterson, Bruce, Harwood, John Leander
• Granted Patent: US 8,629,182 B2
• Time in Patent Office: Days
• US Class Current: 514/560
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A method for modulating enzymatic degradation of articular cartilage in a dog comprises administering to the dog an enzymatic degradation modulating effective amount of eicosapentaenoic acid (EPA), for example as a component of a food composition. By practice of the method in a dog having arthritis, mobility of the dog can be increased, weight bearing in an arthritic limb can be increased, and/or pain associated with arthritis can be reduced.

Claims

1-18. -18. (canceled)

19. A method for modulating enzymatic degradation of articular cartilage in a dog, the method comprising administering to the dog a food composition comprising:

an enzymatic degradation modulating effective amount of eicosapentaenoic acid wherein the concentration of eicosapentaenoic acid is at a concentration of at least 0.4 wt. %; and

a total omega-3 fatty acid content of at least about 3.5 wt. % on a dry matter basis.

20. The method of claim 19, wherein one or more genes responsible for cartilage degradation are down-regulated.

21. The method of claim 19, wherein one or more genes responsible for cartilage degradation are turned off.

22. The method of claim 19, wherein mRNA message expression in cartilage tissue of the dog for an enzyme causing cartilage degradation is reduced.

23. The method of claim 22, wherein the enzyme is an aggrecanase.

24. The method of claim 22, wherein the reduction of mRNA message expression is accompanied by incorporation of eicosapentaenoic acid into membranes of chondrocytes.

25. The method of claim 19, wherein induced release of glycosaminoglycan from cartilage tissue of the dog is decreased.

29. The method of claim 19, wherein the food composition is administered orally in a nutraceutical or pharmaceutical dosage form.

26. (canceled)

28. The method of claim 26, wherein the food composition is a component of a nutritional diet, a snack, a supplement or a treat.

27. (canceled)