Anodal Stimulation Detection and Avoidance

• US 20100262204A1
• Filed: 03/16/2010
• Published: 10/14/2010
• Est. Priority Date: 04/13/2009
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Brisben, Amy Jean, McCabe, Aaron R., Dong, Yanting, Shome, Shibaji
• Granted Patent: US 8,401,639 B2
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.

Claims

1. A cardiac resynchronization therapy system, comprising:

an implantable lead system comprising left and right ventricular electrodes configurable in at least an extended bipolar configuration and at least an alternative bipolar or unipolar configuration differing from the extended bipolar configuration, at least one left ventricular electrode defining a cathode of the extended bipolar configuration and a right ventricular electrode defining an anode of the extended bipolar configuration;

energy delivery circuitry coupled to the lead system;

sensing circuitry coupled to the lead system;

a controller coupled to the sensing circuitry and the energy delivery circuitry, the controller configured to execute program instructions for sensing cardiac electrical activity and delivering cardiac resynchronization therapy (CRT) to the heart in accordance with programmed pacing parameters including a non-zero intraventricular delay (IVD), the controller configured to deliver a pace pulse to the at least one left ventricular electrode defining the cathode of the extended bipolar configuration;

a detector coupled to the sensing circuitry and the controller, the detector configured to sense for a response to the pace pulse and detect anodal stimulation of the right ventricle based on the sensed response; and

the controller is configured to selectably switch from a current extended bipolar pace vector to an alternative bipolar or unipolar pace vector without ganging an additional anode electrode with the right ventricular electrode to mitigate or eliminate detected anodal stimulation of the right ventricle.

2. The system of claim 1, wherein the anode of the current extended bipolar pace vector comprises a single right ventricular ring electrode, and the cathode of the current extended bipolar pace vector comprises at least one of a left ventricular ring electrode or a left ventricular tip electrode.

3. The system of claim 1, wherein the lead system comprises a multiple-pole left ventricular lead comprising a plurality of the left ventricular ring electrodes, at least one of the electrodes of the multiple-pole left ventricular lead defining the cathode of the current extended bipolar pace vector and the anode of the current extended bipolar pace vector comprising a single right ventricular ring electrode.

4. The system of claim 1, wherein the controller is configured to switch from the current extended bipolar pace vector to an alternative unipolar pace vector that excludes the right ventricular electrode and includes at least one left ventricular electrode.

5. The system of claim 1, wherein the controller is configured to switch from the current extended bipolar pace vector to the alternative bipolar pace vector, the alternative bipolar pace vector comprising at least one left ventricular pacing electrode.

6. The system of claim 1, wherein the controller is configured to switch from the current extended bipolar pace vector to the alternative bipolar or unipolar pace vector, the alternative bipolar or unipolar pace vector comprising at least one left ventricular pacing electrodes.

7. The system of claim 1, wherein the controller is configured to switch from the current extended bipolar pace vector to the alternative bipolar pace vector, the alternative bipolar pace vector comprising an extended bipolar pacing electrode configuration differing from the current extended bipolar configuration and comprising at least one left ventricular pacing electrode.

8. The system of claim 7, wherein the controller is configured to switch from the current extended bipolar pace vector to the alternative extended bipolar pace vector.

9. The system of claim 1, wherein the detector is configured to detect presence or absence of an expected right ventricular (RV) sense after a predetermined delay following delivery of the LV pace pulse, wherein presence of the expected RV sense detected after the predetermined delay is indicative of an absence of anodal stimulation of the right ventricle and non-detection of the expected RV sense after the predetermined delay is indicative of anodal stimulation of the right ventricle.

10. The system of claim 1, comprising memory configured to store an expected evoked response template indicative of left ventricular capture responsive to left ventricular pacing using a bipolar or unipolar electrode configuration, wherein the controller is configured to generate a second template indicative of left ventricular capture responsive to left ventricular pacing using the extended bipolar configuration and the detector is configured to detect presence or absence of right ventricular anodal stimulation based on a comparison of the expected evoked response template and the second template.

11. The system of claim 1, wherein the controller is configured to enable a right ventricular capture verification test during an left ventricular threshold test.

12. The system of claim 1, wherein the controller is configured to deliver a predetermined number of left ventricular pace pulses using the extended bipolar configuration and the detector is configured to detect a number of right ventricular capture events responsive to the predetermined number of left ventricular pace pulses, the detector configured to detect right ventricular anodal stimulation based on a comparison of the number of right ventricular capture events relative to the predetermined number of left ventricular pace pulses.

13. The system of claim 1, wherein the detector is configured to detect right ventricular anodal stimulation during a left ventricular capture threshold test.

14. The system of claim 1, wherein the controller is configured to implement a left ventricular (LV) capture threshold test using the extended bipolar configuration, the detector is configured to detect LV capture and right ventricular (RV) anodal stimulation during the LV capture threshold test and determine an LV capture threshold value and an RV anodal stimulation threshold value.

15. The system of claim 1, wherein the detector is configured to detect right ventricular (RV) anodal stimulation resulting from a left ventricular (LV) test pace based on a comparison of:

an LV evoked response template developed from LV responses to a predetermined number of LV paces during extended bipolar pacing; and

an expected LV evoked response morphological template developed from LV responses to a predetermined number of LV paces during bipolar or unipolar LV pacing.

16. The system of claim 1, wherein the detector is configured to detect fusion or non-capture based on a comparison of:

a left ventricular (LV) evoked response template developed from LV responses to a predetermined number of LV paces that do not result in right ventricular anodal stimulation; and

a second LV evoked response template developed from LV responses to a predetermined number of LV paces that result in right ventricular anodal stimulation.

17. The system of claim 1, wherein the controller is configured to implement a left ventricular (LV) capture threshold test using the extended bipolar configuration, the detector configured to detect LV capture, right ventricular (RV) anodal stimulation, and fusion/non-capture during the LV capture threshold test and determine an LV capture threshold value and an RV anodal stimulation threshold value.

18. A method of delivering cardiac resynchronization therapy, comprising:

selectably delivering cardiac resynchronization therapy (CRT) to a heart using at least an extended bipolar electrode configuration and at least an alternative bipolar or unipolar electrode configuration differing from the extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay (IVD), the extended bipolar electrode configuration comprising at least a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a single right ventricular electrode defining an anode of the extended bipolar electrode configuration;

delivering a pace pulse to the left ventricular electrode;

sensing for a response to the pace pulse;

detecting anodal stimulation of the right ventricle based on the sensed response; and

switching from a current extended bipolar pace vector to an alternative bipolar or unipolar pace vector without ganging an additional anode electrode with the single right ventricular electrode to mitigate or eliminate detected anodal stimulation of the right ventricle.

19. The method of claim 18, wherein:

the anode of the current extended bipolar pace configuration comprises the single right ventricular ring electrode;

the cathode of the current extended bipolar pace configuration comprises at least one left ventricular pace electrode; and

the alternative bipolar pace configuration comprises at least one left ventricular pace electrode.

20. The method of claim 18, wherein switching from the current extended bipolar pace vector to the alternative bipolar pace vector comprises switching to an alternative extended bipolar pace vector differing from the current extended bipolar pace vector and comprising at least one left ventricular pace electrode.

21. The method of claim 18, wherein switching from the current extended bipolar pace vector to the alternative unipolar pace vector comprises switching to the alternative unipolar pace vector that includes at least one left ventricular electrode and excludes the single right ventricular electrode.

22. The method of claim 18, comprising:

storing an expected evoked response template indicative of left ventricular capture responsive to left ventricular pacing using a bipolar or unipolar electrode configuration;

generating a second template indicative of left ventricular capture responsive to left ventricular pacing using the extended bipolar electrode configuration; and

detecting presence or absence of right ventricular anodal stimulation based on a comparison of the expected evoked response template and the second template.

23. The method of claim 18, comprising:

comparing a left ventricular (LV) evoked response template, developed from LV responses to a predetermined number of LV paces during extended bipolar pacing, to an expected LV evoked response morphological template developed from LV responses to a predetermined number of LV paces during bipolar or unipolar LV pacing; and

detecting right ventricular anodal stimulation resulting from an LV test pace based on the comparison.

24. The method of claim 18, comprising:

comparing a left ventricular (LV) evoked response template, developed from LV responses to a predetermined number of LV paces that do not result in right ventricular anodal stimulation, to a second LV evoked response template developed from LV responses to a predetermined number of LV paces that result in right ventricular anodal stimulation; and

detecting fusion or non-capture based on the comparison.

25. The method of claim 18, comprising:

comparing a left ventricular (LV) evoked response template, developed from LV responses to a predetermined number of LV paces that do not result in right ventricular anodal stimulation, and a second LV evoked response template, developed from LV responses to a predetermined number of LV paces that result in right ventricular anodal stimulation; and

detecting fusion or non-capture based on the comparison.

26. The method of claim 18, comprising:

implementing a left ventricular (LV) capture threshold test using the extended bipolar configuration; and

detecting LV capture, right ventricular anodal stimulation, and one or both of fusion and non-capture during the LV capture threshold test; and

determining an LV capture threshold value and an RV anodal stimulation threshold value.

27. The method of claim 18, comprising:

modifying one or more left ventricular (LV) pacing parameters to mitigate or eliminate detected anodal stimulation of the right ventricle without physician intervention of left ventricular pacing parameter modification; and

switching from the current extended bipolar pace vector to an alternative bipolar or unipolar pace vector in response of LV pacing parameter modification failing to mitigate or eliminate detected anodal stimulation of the right ventricle.

28. A system for delivering cardiac resynchronization therapy, comprising:

means for selectably delivering cardiac resynchronization therapy (CRT) to a heart using at least an extended bipolar electrode configuration and at least an alternative bipolar or unipolar electrode configuration differing from the extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay (IVD), the extended bipolar electrode configuration comprising at least a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a single right ventricular electrode defining an anode of the extended bipolar electrode configuration;

energy delivery circuitry configured to deliver a pace pulse to the left ventricular electrode;

sensing circuitry configured to sense for a response to the pace pulse;

means for detecting anodal stimulation of the right ventricle based on the sensed response; and

means for switching from a current extended bipolar pace vector to an alternative bipolar or unipolar pace vector without ganging an additional anode electrode with the right ventricular electrode to mitigate or eliminate detected anodal stimulation of the right ventricle.