Pocket-enabled chip assembly for implantable devices

• US 20100265680A1
• Filed: 01/21/2010
• Published: 10/21/2010
• Est. Priority Date: 01/21/2009
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Huang, Ray Kui-Jui, Tai, Yu-Chong
• Granted Patent: US 8,824,156 B2
• Time in Patent Office: Days
• US Class Current: 361/760
• CPC Class Codes: A61B 2562/0215 Silver or silver chloride containing
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/293 Invasive
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36038 Cochlear stimulation
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

Systems and methods for providing biologically compatible pockets or envelopes that can contain chips and other circuit elements and can make electrical connection between those elements and living organisms. The assembled biologically compatible pockets and circuit components can have biomedical applications, such as bioimplantable devices such as retinal, cochlear and cortical prosthesis implants, muscular stimulators, and other uses. In various embodiments, the described technology explains how to make and use pocket systems for dealing with chips having connectors on one or two surfaces, and with other circuit components such as resistors, capacitors, inductors and transistors. Operation of chips encapsulated according to the described technology is demonstrated. Accelerated life testing suggests that the pocket systems described will survive for years at 37 degrees C.

Claims

1. A biocompatible sealable pocket, comprising;

a substrate having a first surface; and

a layer of a biocompatible material connected to said first surface of said substrate, said layer of said biocompatible material defining an open pocket between said biocompatible substrate and said layer of said biocompatible material, said open pocket having at least one electrical contact configured to be accessible on an internal surface thereof, said open pocket configured to accept at least one electrical circuit component and to provide electrical communication between said at least one electrical contact and said at least one electrical circuit component, said biocompatible sealable pocket configured to be sealed and to be implanted within a living organism after accepting said at least one electrical circuit component, said biocompatible sealable pocket configured to provide a biocompatible object capable of biologically significant electrical communication with said living organism within which said biocompatible sealable pocket is implanted.

2. The biocompatible sealable pocket of claim 1, wherein said substrate having a first surface comprises parylene.

3. The biocompatible sealable pocket of claim 1, wherein said substrate having a first surface comprises silicon.

4. The biocompatible sealable pocket of claim 1, wherein said layer of biocompatible material comprises parylene.

5. The biocompatible sealable pocket of claim 1, wherein said open pocket having at least one electrical contact configured to be accessible on an internal surface thereof has electrical contacts on at least two internal surfaces thereof.

6. The biocompatible sealable pocket of claim 1, further comprising an electrical cable having electrical conductors therein configured to make electrical connection between at least one probe element and at least one electrical circuit component situated with said pocket, said probe element configured to make electrical connection to said living organism within which said biocompatible sealable pocket is implanted.

7. The biocompatible sealable pocket of claim 1, further comprising an electrical signal communication device configured to communicate an electrical signal between said at least one electrical circuit component and an electrical circuit external to said living organism.

8. The biocompatible sealable pocket of claim 1, wherein said electrical signal communication device comprises a coil configured to make electromagnetic connection between said at least one electrical circuit component and an electrical circuit external to said living organism.

9. The biocompatible sealable pocket of claim 8, further comprising a tuning circuit configured to allow operation with an electromagnetic communication signal having predefined electrical parameters.

10. The biocompatible sealable pocket of claim 1, wherein said electrical signal communication device comprises a cable configured to make electromagnetic connection between said at least one electrical circuit component and an electrical circuit external to said living organism.

11. The biocompatible sealable pocket of claim 1, comprising;

a substrate having a first surface; and

a layer of a biocompatible material connected to said first surface of said substrate, said structure of said layer of biocompatible material defining an open pocket between said biocompatible substrate and said layer of said biocompatible material, said open pocket having at least one electrical contact configured to be accessible on an internal surface thereof, said open pocket configured to accept at least one electrical circuit component and to provide electrical communication between said at least one electrical contact and said at least one electrical circuit component, said biocompatible sealable pocket configured to be sealed and to be implanted within a living organism after accepting said at least one electrical circuit component, said biocompatible sealable pocket configured to provide a biocompatible object capable of biologically significant electrical communication with said living organism within which said biocompatible sealable pocket is implanted;

in combination with;

at least one electrical circuit component situated with said pocket and electrically connected to said at least one electrical connector;

at least one probe configured to make electrical connection to a living organism and connected to said at least one electrical circuit component; and

an electrical communication device configured to communicate an electrical signal between said at least one electrical circuit component and an electrical circuit external to said living organism.

19. The biocompatible sealable pocket of claim 1, wherein said layer of biocompatible material comprises a material selected from the group consisting of PMMA, teflon, silicone and polyimide.

12. A method of making a biocompatible sealable pocket, comprising the steps of:

a. providing a substrate having a first surface;

b. depositing a layer of a sacrificial material having a predefined length, a predefined width, and a predefined thickness on a portion of said surface of said substrate;

c. depositing a layer of a biocompatible material over said layer of said sacrificial material, said layer of said biocompatible material extending beyond said sacrificial material;

d. depositing a layer of a conductive material over at least a portion of said layer of said biocompatible material;

e. depositing a second layer of a biocompatible material over said layer of said conductive material, said layer of said biocompatible material extending beyond said conductive material;

f. providing openings in said second layer of said biocompatible material to provide electrical access to said conductive material through said second layer of said biocompatible material; and

g. removing said sacrificial material to define a free volume having said predefined length, said predefined width, and said predefined thickness, said free volume configured to accept at least one electrical circuit component;

whereby said free volume represents an open pocket having at least one electrical contact configured to be accessible on an internal surface thereof, said open pocket configured to accept at least one electrical circuit component and to provide electrical communication between said at least one electrical contact and said at least one electrical circuit component, said biocompatible sealable pocket configured to be sealed and to be implanted within a living organism after accepting said at least one electrical circuit component, said biocompatible sealable pocket configured to provide a biocompatible object capable of biologically significant electrical communication with said living organism within which said biocompatible sealable pocket is implanted.

13. The method of making a biocompatible sealable pocket of claim 12, further comprising the steps of

after the step 12a. of providing substrate, and before the step 12b. of depositing a layer of a sacrificial material,

13(i) depositing on said surface of said substrate a layer of a biocompatible material, said layer of said biocompatible material having a length greater than said predefined length of said sacrificial material, said layer of said biocompatible material having a width greater than said predefined width of said sacrificial material;

whereby said free volume represents an open pocket having a biocompatible material as each of its defining surfaces.

14. The method of making a biocompatible sealable pocket of claim 13, further comprising the step of

releasing said biocompatible sealable pocket from said substrate, to provide a self-supporting free standing biocompatible sealable pocket.

15. The method of making a biocompatible sealable pocket of claim 13, further comprising the steps of;

after the step 13(i) of depositing on said surface of said substrate a layer of a biocompatible material, and before the step 12b. of depositing a layer of a sacrificial material,

15(ii) depositing a layer of a conductive material over at least a portion of said layer of said biocompatible material;

15(iii) depositing a layer of a biocompatible material over said layer of said conductive material, said layer of said biocompatible material extending beyond said conductive material; and

15(iv) providing openings in said layer of said biocompatible material deposited in step 15(iii) to provide electrical access to said conductive material through said layer of said biocompatible material deposited in step 15(iii); and

after the step 12f. of providing openings, and before the step 12g. of removing said sacrificial material,

15(v) providing openings in said layers deposited in steps 15(iii), and 12b, 12c, 12d and 12e, to provide electrical access to said conductive material deposited in step 15 (ii) through said layer of said biocompatible material deposited in step 15(iii);

whereby there is provided a biocompatible sealable pocket having electrical contacts on two interior surfaces thereof.

16. The method of making a biocompatible sealable pocket of claim 15, further comprising the steps of

releasing said biocompatible sealable pocket from said substrate, to provide a self-supporting free standing biocompatible sealable pocket.

17. The method of making a biocompatible sealable pocket of claim 12, wherein said layer of biocompatible material comprises parylene

18. The method of making a biocompatible sealable pocket of claim 12, wherein said layer of biocompatible material comprises a material selected from the group consisting of PMMA, teflon, silicone and polyimide.