IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS
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Accused Products
Abstract
The invention provides methods of immunotherapy of Alzheimer'"'"'s and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
119 Citations
201 Claims
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1-127. -127. (canceled)
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128. A method of treating or effecting prophylaxis of a disease characterized by Aβ
- deposits in the brain of patient comprising administering an effective regime of a humanized antibody to the patient;
wherein the humanized antibody comprises a mature light chain variable region sequence of SEQ ID NO;
2 and a mature heavy chain variable region sequence of SEQ ID NO;
3, and a human heavy chain constant of IgG1 isotype with L234A, L235A, and G237A mutations, wherein position are numbered by the EU numbering system. - View Dependent Claims (129, 130, 131, 132, 133, 196, 197, 198, 199, 200, 201)
- deposits in the brain of patient comprising administering an effective regime of a humanized antibody to the patient;
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134-195. -195. (canceled)
Specification