Death Domain Containing Receptors
First Claim
1. An isolated antibody which binds to a polypeptide selected from the group consisting of:
- (a) amino acids 1 to 428 of SEQ ID NO;
2; and
(b) amino acids 1 to 417 of SEQ ID NO;
4.
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Accused Products
Abstract
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
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Citations
20 Claims
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1. An isolated antibody which binds to a polypeptide selected from the group consisting of:
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(a) amino acids 1 to 428 of SEQ ID NO;
2; and(b) amino acids 1 to 417 of SEQ ID NO;
4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An isolated polypeptide comprising an amino acid sequence at least 95% identical to:
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(a) amino acids 36 to 212 of SEQ ID NO;
2;(b) amino acids 30 to 217 of SEQ ID NO;
2;(c) amino acids 30 to 428 of SEQ ID NO;
2; and(d) amino acids 1 to 428 of SEQ ID NO;
2. - View Dependent Claims (14, 15, 16)
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17. An isolated polypeptide comprising an amino acid sequence at least 95% identical to:
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(a) amino acids 1 to 417 of SEQ ID NO;
4;(b) amino acids 25 to 417 of SEQ ID NO;
4; and(c) amino acids 25 to 201 of SEQ ID NO;
4. - View Dependent Claims (18, 19, 20)
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Specification