METHODS OF PROMOTING ENHANCED HEALING OF TISSUES AFTER CARDIAC SURGERY

• US 20100266662A1
• Filed: 04/26/2010
• Published: 10/21/2010
• Est. Priority Date: 09/10/2002
• Status: Abandoned Application

• Current Assignee: MAST Biosurgery AG
• Original Assignee: MAST Biosurgery AG
• Inventors: Calhoun, Christopher J.
• Application Number:
  US12/767,701
• Publication Number:
  US 20100266662A1
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61B 2090/0816 for preventing adhesion
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Resorbable polylactide polymer healing membranes and methods of their applications are disclosed. In a broad embodiment, the invention features methods for inducing proper tissue healing after an open heart surgery. In one embodiment, the methods includes a step of forming a patch with a healing membrane over the open pericardium to induce proper tissue healing and placement in other open heart surgery procedures to facilitate re-entry by the surgeon.

Claims

1. A method for promoting healing of damaged tissue after an open heart surgery, the method comprising:

providing a substantially planar healing membrane, which is;

(a) substantially-smooth on at least one side;

(b) substantially uniform in composition;

(c) about 10 microns to about 300 microns in thickness;

(d) non-porous;

(e) constructed from a resorbable polymer base material being a poly-lactide polymer and a copolymer of lactides, the poly-lactide polymer and copolymer of lactides being 70;

30 poly (L-lactide-co-D,L-lactide); and

(f) adapted to be resorbed into the mammalian body within a period of approximately 18 to 24 months from an initial implantation of the membrane into the mammalian body;

placing the healing membrane adjacent to pericardial tissue of a patient whereby the pericardial tissue surrounding the opening can regenerate along the membrane; and

applying a surgical instrument through the membrane and tissue.

2. The method of claim 1, wherein the thickness of the membrane is about 100 microns.

3. The method of claim 1, wherein the thickness of the membrane is about 200 microns.

4. The method of claim 1, wherein the healing membrane is provided in a sterile packaging.

5. The method of claim 1, wherein the step of placing the healing membrane in a patient is effective to attenuate tissue adhesion.

6. The method of claim 1, further comprising a step of attaching the healing membrane to the pericardial tissue.

7. The method of claim 6, wherein the attaching step comprises heat bonding the membrane to the pericardial tissue.

8. The method of claim 1, wherein the healing membrane is precontoured to a heart-shape and the placing comprises placing the healing membrane onto the apex of a heart.

9. The method of claim 1, wherein:

the providing comprises providing a healing membrane precontoured into a tube; and

the placing comprises placing the healing membrane around the conduit of a left-ventricular assist device (LVAD).

10. The method of claim 1, wherein:

the providing comprises providing a healing membrane precontoured; and

the placing comprises placing the healing membrane over a pump of a left-ventricular assist device (LVAD).

13. The method of claim 7, wherein the providing comprises providing a membrane comprising angiotensin antagonists.

11. A method for promoting healing of damaged tissue after an open heart surgery, the method comprising:

providing a substantially planar healing membrane, which is;

(a) substantially-smooth on at least one side;

(b) substantially uniform in composition;

(c) about 10 microns to about 300 microns in thickness;

(d) non-porous;

(e) constructed from a resorbable polymer base material being a poly-lactide polymer and the poly-lactide polymer being poly-L-lactide; and

(f) adapted to be resorbed into the mammalian body within a period of approximately 18 to 24 months from an initial implantation of the membrane into the mammalian body;

placing the healing membrane adjacent to pericardial tissue of a patient whereby the pericardial tissue surrounding the opening can regenerate along the membrane; and

applying a surgical instrument through the membrane and tissue.

12. A method for promoting healing of damaged tissue after an open heart surgery, the method comprising:

providing a substantially planar healing membrane, which is;

(a) substantially-smooth on at least one side;

(b) substantially uniform in composition;

(c) about 10 microns to about 300 microns in thickness;

(d) non-porous;

(e) constructed from a resorbable polymer base material selected from the group consisting essentially of (i) a poly-lactide polymer, (ii) a copolymer of lactides, and (iii) a poly-lactide polymer and a copolymer of lactides; and

(f) adapted to be resorbed into the mammalian body within a period of approximately 18 to 24 months from an initial implantation of the membrane into the mammalian body;

placing the healing membrane adjacent to pericardial tissue of a patient whereby the pericardial tissue surrounding the opening can regenerate along the membrane, the placing of the healing membrane in a patient being effective to attenuate formation of scar tissue; and

applying a surgical instrument through the membrane and tissue.

14. The method of claim 12, wherein the placing comprises affixing.

15. The method of claim 12, wherein the applying comprises applying sutures or staples.

16. The method of claim 12, wherein the thickness of the membrane is about 100 microns.

17. The method of claim 12, wherein the thickness of the membrane is about 200 microns.

18. The method of claim 12, wherein the healing membrane is provided in a sterile packaging.

19. The method of claim 12, wherein the step of placing the healing membrane in a patient is effective to attenuate tissue adhesion.

20. The method of claim 19, wherein the attaching step comprises heat bonding the membrane to the pericardial tissue.