Sequencing Nucleic Acid Polymers with Electron Microscopy
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Abstract
This invention relates to using an electron microscope to sequence by direct inspection of labeled, stretched DNA. This method will have higher accuracy, lower cost, and longer read length than current DNA sequencing methods.
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Citations
113 Claims
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1-93. -93. (canceled)
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94. A method of providing consistent base-to-base spacing in a polymer, the method comprising:
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a) introducing a polymeric binding tool into a fluid composition of the polymer so that the polymer binds to the polymer binding tool; and b) removing the polymer binding tool from the fluid so that the polymer is stretched into space between an air/fluid interface and the polymer binding tool; to provide consistent base-to-base spacing in the polymer. - View Dependent Claims (95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108)
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109. A method comprising:
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a) introducing a polymer binding tool into a fluid composition of a polymer so that the polymer binds to the polymer binding tool; and b) removing the polymer binding tool from the fluid so that the polymer is stretched into space between an air/fluid interface and the polymer binding tool. - View Dependent Claims (110, 111, 112, 113)
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Specification