MEASUREMENT OF HEMATOCRIT AND CARDIAC OUTPUT FROM OPTICAL TRANSMISSION AND REFLECTION CHANGES

• US 20100268090A1
• Filed: 11/05/2008
• Published: 10/21/2010
• Est. Priority Date: 11/06/2007
• Status: Abandoned Application

• Current Assignee: The Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California (University of Southern California)
• Original Assignee: The Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California (University of Southern California)
• Inventors: Rubinstein, Eduardo H., Holschneider, Daniel P., Maarek, Jean-Michel I.
• Application Number:
  US12/741,585
• Publication Number:
  US 20100268090A1
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53

Abstract

A system and method of non-invasive determination of hematocrit change from optical reflected light in combination with transmitted light or from reflected light measured from one or more locations on a blood carrying medium. Determining the cardiac output of a patient based on the amount of plasma or saline injected and the determined hematocrit change. The cardiac output may be determined on a patient undergoing hemodialysis. The hematocrit changes can be detected transcutaneously, transarterially, intraarterially, or across an extracorporeal arterial circulatory path.

Claims

1. A method of determining cardiac output of a subject comprising:

a) illuminating the cardiovascular system of the subject with an excitation light;

b) detecting the intensity (x) of the excitation light that is reflected by a portion of the cardiovascular system;

c) detecting the intensity (y) of the excitation light that is transmitted through a portion of the cardiovascular system;

d) determining the concentration of hematocrit from the ratio of (y)/(x);

e) injecting a predetermined quantity of fluid into the cardiovascular system;

f) repeating steps a) through d);

g) determining the hematocrit change trace integrated over time; and

h) determining the subjects'"'"' cardiac output based on the quantity of injected fluid and the hematocrit change trace integrated over time.

2. The method of claim 1, wherein the detection steps can be performed transcutaneously, tranarterially, intraarterially or across an extracorporeal arterial circulatory path.

3. The method of claim 1, wherein the first wavelength is selected from a range of about 488 nm to about 1000 nm.

4. The method of claim 1, wherein the injected fluid comprises saline or plasma.

5. A method of determining cardiac output of a subject comprising:

a) illuminating the cardiovascular system of the subject with an excitation light;

b) detecting the intensity (x) of the excitation light that is reflected by a portion of the cardiovascular system at a first location;

c) detecting the intensity (y) of the excitation light that is reflected by a portion of the cardiovascular system at a second location;

d) determining the concentration of hematocrit from the ratio of (y)/(x);

e) injecting a predetermined quantity of fluid into the cardiovascular system;

f) repeating steps a) through d);

g) determining the hematocrit change trace integrated over time; and

h) determining the subjects'"'"' cardiac output based on the quantity of injected fluid and the hematocrit change trace integrated over time.

6. The method of claim 5, wherein the detection steps can be performed transcutaneously, tranarterially, intraarterially or across an extracorporeal arterial circulatory path.

7. The method of claim 5, wherein the first wavelength is selected from a range of about 488 nm to about 1000 nm.

8. The method of claim 5, wherein the injected fluid comprises saline or plasma.

9. A system for determining cardiac output of a subject comprising:

a) an illumination source configured to be positioned proximately to at least one blood vessel of the cardiovascular system to provide a wavelength of light to the cardiovascular system;

b) at least one photodetector configured to be positioned proximate to the cardiovascular system of the subject so as to detect information regarding the intensity (x) of the excitation light that is reflected by a portion of the cardiovascular system and to detect information regarding the intensity (y) of the excitation light that is transmitted through the cardiovascular system, and to detect a quantity of injected fluid in the cardiovascular system; and

c) a computing system configured to receive the detected intensity information from the photodetector and to determine the concentration of hematocrit from the ratio of (y)/(x); and

configured to compute a hematocrit change trace integrated over time; and

further configured to determine the subjects'"'"' cardiac output based on the measured quantity of injected fluid and the computed hematocrit change trace integrated over time.

10. The system of claim 9, wherein the photodetector is configured for placement in at least one of a transdermal detection area, a subdermal detection area, a perivascular detection area or an endovascular detection area.

11. The system of claim 9, wherein the first wavelength is selected from a range of about 488 nm to about 1000 nm.

12. The system of claim 9, wherein the injected fluid comprises saline or plasma.