Monitoring Peripheral Decoupling
First Claim
1. A method for monitoring central-to-peripheral arterial pressure decoupling in a subject comprising:
- providing arterial pressure waveform data from the subject;
applying a first multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s first arterial tone, the first multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects that were experiencing central-to-peripheral arterial pressure decoupling, the first multivariate statistical model providing a value for the subject'"'"'s first arterial tone;
applying a second multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s normal arterial tone, the second multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects with normal hemodynamic conditions, the second multivariate statistical model providing a value for the subject'"'"'s second arterial tone; and
comparing the subject'"'"'s first arterial tone to the subject'"'"'s second arterial tone,wherein a difference between the subject'"'"'s first arterial tone and the subject'"'"'s second arterial tone greater than a threshold value indicates the subject is experiencing central-to-peripheral arterial pressure decoupling.
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Abstract
Methods for monitoring central-to-peripheral arterial pressure decoupling, i.e., hyperdynamic conditions, are described. These methods involve the comparison of parameters calculated from multivariate statistical models established for both subjects experiencing normal hemodynamic conditions and subjects experiencing hyperdynamic conditions, in which central- to peripheral decoupling may occur. The difference or ratio between the parameters calculated using the two multivariate statistical models provides a continual indication of the level of decoupling as well as indicating peripheral decoupling when a threshold value is exceeded. These methods can be used to both alert a user to the fact that a subject is experiencing peripheral decoupling and provide accurate arterial tone measurements, which enable the calculation of accurate values for other parameters, such as stroke volume and cardiac output.
12 Citations
31 Claims
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1. A method for monitoring central-to-peripheral arterial pressure decoupling in a subject comprising:
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providing arterial pressure waveform data from the subject; applying a first multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s first arterial tone, the first multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects that were experiencing central-to-peripheral arterial pressure decoupling, the first multivariate statistical model providing a value for the subject'"'"'s first arterial tone; applying a second multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s normal arterial tone, the second multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects with normal hemodynamic conditions, the second multivariate statistical model providing a value for the subject'"'"'s second arterial tone; and comparing the subject'"'"'s first arterial tone to the subject'"'"'s second arterial tone, wherein a difference between the subject'"'"'s first arterial tone and the subject'"'"'s second arterial tone greater than a threshold value indicates the subject is experiencing central-to-peripheral arterial pressure decoupling. - View Dependent Claims (3, 6, 8, 9, 16, 17, 21, 25, 26)
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2. A method for monitoring central-to-peripheral arterial pressure decoupling in a subject comprising:
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providing arterial pressure waveform data from the subject; applying a first multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s first arterial tone, the first multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects that were experiencing central-to-peripheral arterial pressure decoupling, the first multivariate statistical model providing a value for the subject'"'"'s first arterial tone; applying a second multivariate statistical model to the arterial pressure waveform data to determine the subject'"'"'s normal arterial tone, the second multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects with normal hemodynamic conditions, the second multivariate statistical model providing a value for the subject'"'"'s second arterial tone; and comparing the subject'"'"'s first arterial tone to the subject'"'"'s second arterial tone, wherein a ratio of the subject'"'"'s first arterial tone to the subject'"'"'s second arterial tone greater than a threshold ratio indicates the subject is experiencing central-to-peripheral arterial pressure decoupling. - View Dependent Claims (12, 13, 19, 22, 27, 28, 29, 30, 31)
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4-5. -5. (canceled)
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7. (canceled)
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10-11. -11. (canceled)
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14-15. -15. (canceled)
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18. (canceled)
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20. (canceled)
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23-24. -24. (canceled)
Specification