ESOPHAGEAL ACTIVITY MODULATED OBESITY THERAPY
First Claim
1. A method of modulating a component of the nervous system of a mammal, the method comprising:
- providing a sensor, wherein the sensor is configured to produce a first sensor output signal associated with the onset of a period of nutrient consumption, and a second sensor output signal, associated with the end of a period of nutrient consumption;
providing a stimulator configured to output a first therapeutic signal in response to the first sensor output signal, and a second therapeutic signal in response to the second sensor output signal;
wherein applying the first therapeutic signal to a first component of the nervous system is effective to mimic satiety in the mammal; and
wherein applying the second therapeutic signal to a second component of the nervous system is effective to produce an increase in energy expenditure in the mammal.
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Accused Products
Abstract
Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.
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Citations
53 Claims
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1. A method of modulating a component of the nervous system of a mammal, the method comprising:
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providing a sensor, wherein the sensor is configured to produce a first sensor output signal associated with the onset of a period of nutrient consumption, and a second sensor output signal, associated with the end of a period of nutrient consumption; providing a stimulator configured to output a first therapeutic signal in response to the first sensor output signal, and a second therapeutic signal in response to the second sensor output signal; wherein applying the first therapeutic signal to a first component of the nervous system is effective to mimic satiety in the mammal; and wherein applying the second therapeutic signal to a second component of the nervous system is effective to produce an increase in energy expenditure in the mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10-32. -32. (canceled)
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33. A method of modulating a component of the nervous system of a mammal, the method comprising:
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sensing the onset of eating in the mammal; and stimulating a splanchnic nerve responsive to the eating sensing by applying at least one electrical stimulus dose, in which the dose has a stimulation duration of at least about ¼
hour and has a frequency which varies much more than the intensity;in which the method has a reduced intensity or no intensity interval after the dose at least about 1 hour in length. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42)
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43-52. -52. (canceled)
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53. A method of modulating a component of the nervous system of a mammal, the method comprising:
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sensing the onset of eating in the mammal; and stimulating a splanchnic nerve responsive to the eating sensing by applying at least one electrical stimulus first dose, in which the first dose has a stimulation duration of at least about ¼
hour and has a frequency which varies much more than the intensity;in which the method follows the varying frequency first dose with an increasing intensity second dose configured to stimulate more efferently than the first dose and to capture more fibers than the first dose.
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Specification