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Method And Apparatus For Rapid Electrochemical Analysis

  • US 20100270178A1
  • Filed: 07/02/2010
  • Published: 10/28/2010
  • Est. Priority Date: 09/30/2005
  • Status: Active Grant
First Claim
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1. A method for determining an analyte concentration in a physiological sample, the method comprising:

  • (a) introducing the physiological sample into an electrochemical cell comprising;

    (i) first and second electrodes in a spaced apart relationship; and

    (ii) a reagent layer comprising an enzyme and a mediator;

    (b) applying a first electric potential having a first polarity to the reaction cell and measuring cell current as a function of time to obtain a first time-current transient;

    (c) applying a second electric potential having a second polarity to the cell, wherein the second polarity is opposite the first polarity, and measuring cell current as a function of time to obtain a second time-current transient; and

    (d) calculating a first current value from the second time-current transient;

    (e) calculating a second current value from the second time-current transient and a third current value from the first time-current transient;

    (f) calculating a ratio which comprises the second current value divided by the third current value; and

    (g) multiplying the first current value less a background value by the ratio to derive analyte concentration.

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