ANALYTICAL DESIGN OF INTRAOCULAR LENSES

• US 20100271591A1
• Filed: 04/29/2008
• Published: 10/28/2010
• Est. Priority Date: 05/07/2007
• Status: Abandoned Application

• Current Assignee: Consejo Superior de Investigaciones Científicas,
• Original Assignee: Consejo Superior de Investigaciones Científicas,
• Inventors: Barbero Briones, Sergio, Dorronsoro Diaz, Carlos, Marcos Celestino, Susana
• Application Number:
  US12/599,047
• Publication Number:
  US 20100271591A1
• Time in Patent Office: Days
• US Class Current: 351/177
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61F 2/1613 having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
• CPC Class Codes: A61F 2240/002 Designing or making customized prostheses

Abstract

The invention relates to a method for designing intraocular lenses, comprising: the definition of a pseudoaphakic eye model; the definition of a merit function in multiple dimensions, which analytically connects the quality of the image on the retina to the optical and geometric parameters of the pseudoaphakic eye model; and the algorithm optimisation of the previous merit function using analytical and numerical methods in order to obtain one or more minimum globals which provide the optimal parameters of the intraocular lens for the pseudoaphakic eye model.

Claims

1. Procedure for the design of intraocular lenses, wherein it comprises the following stages:

a) Definition of a pseudophakic eye model, which consists of;

i. an aphakic eye model that comprises various optical surfaces, refractive indices and thicknesses that describe the optical elements of the eye without the crystalline lens, and

ii. an intraocular lens model that comprises a succession of optical surfaces and separated by layers of material described by their thickness and refractive index,

b) Definition of a merit function in various dimensions that relates analytically the quality of the image in the retina with the optical and geometric parameters of the pseudophakic eye model, wherein the parameters of the aphakic eye model are established as fixed terms and the parameters of the intraocular lens are considered variable terms, and

c) The algorithmic optimisation of the merit function above by analytical and numerical means in order to find one or several global minimums from which the optimum parameters of the intraocular lens can be obtained for the established pseudophakic eye model.

2. Procedure according to claim 1, wherein the aphakic eye model is established by the inclusion of the mean biometric parameters of the eyes of a population of patients that may be grouped according to different indices related to said biometric parameters, such as age or refractive error.

3. Procedure according to claim 1 wherein the aphakic eye model is developed including some of the biometric parameters of a given patient, such as corneal geometry, intraocular distances and pupil diameter.

4. Procedure according to claim 1 wherein the generation of a merit function comprises the following stages:

a) Evaluation of defocus in the paraxial plane given by the eye model, using the matrix formalism of paraxial ray transfer,

b) Evaluation of the spherical aberration in the paraxial plane using the third order aberration theory,

c) Application of an analytical corrective factor, using a plane change equation, for a better estimation of both spherical aberration and defocus in the retina plane,

d) Obtaining the wave aberration variance function based on the previous equations and, as a final merit function, the equivalent in dioptres corresponding to said variance.

5. Procedure according to claim 1 wherein the optimisation of the merit function is carried out by analytically obtaining the partial derivatives of the multidimensional merit function and obtaining a global minimum (or several local minimums) across the gradients thus calculated.

6. Procedure according to claim 1, wherein both in the pseudophakic eye model as well as in the calculation and optimisation of the multidimensional merit function refractive indices are included that depend on the wave length (dispersion formulae).

7. Procedure according to claim 1, wherein the multidimensional merit function incorporates optical quality parameters for different distances of the target plane, it being possible to extend said procedure to the design of multifocal intraocular lenses.

8. Procedure according to claim 1, wherein in the aphakic eye model the cornea is considered to be an element with multiple optical layers, defined by its border surfaces, thicknesses and refractive indices.

9. Procedure according to claim 4 wherein the generation of the merit function can be carried out using the optical metrics calculated analytically on the basis of the spherical aberration and the defocus in the retina calculated previously.

10. Procedure according to claim 9 wherein the metrics used is visual metrics that include the expected response of the visual system to the retinal optical stimulus.

11. Procedure according to claim 9 wherein the metrics used includes the estimation of the diffractives on the image plane.

12. A method for the analysis of tolerances for the lens in manufacturing and quality control processes, which comprises implementing the procedure for the design of intraocular lenses as recited in claim 1.