DETERMINATION OF TRACERS WITHIN SUBJECTS
First Claim
1. A method, comprising:
- providing a substance, the presence and/or amount of which is to be determined in association with a subject;
offering, to the subject, a composition comprising the substance and a tracer able to be introduced into and be determined in association with the subject; and
determining whether the substance was administered to the subject by determining the tracer in association with the subject.
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention generally relates to the use of tracers, for example, to track a substance that has been administered to a subject. A tracer may be separate from the substance to be administered, or in some cases, the tracer and the substance are chemically bonded to each other. When administered to a subject (e.g., ingested), the tracer and the substance to be administered may be absorbed and/or metabolized by the subject, and the pharmacokinetic activity of the tracer within the subject may be related to the pharmacokinetic activity of the substance. Thus, by following the pharmacokinetic activity of the tracer, the pharmacokinetic activity of the substance may be determined. The tracer itself may be determined within a subject using any suitable method, depending on the tracer. As an example, the tracer may be determined by administering an indicator able to interact with the tracer. For instance, the indicator may be applied to the skin of the subject, and the indicator may give a different visual appearance based on the concentration of the tracer, or otherwise exhibit a determinable change in a property of the indicator. Other aspects of the invention are generally directed to methods of making or using tracers, methods of promoting the making or use of such tracers, kits involving such tracers, and the like.
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Citations
158 Claims
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1. A method, comprising:
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providing a substance, the presence and/or amount of which is to be determined in association with a subject; offering, to the subject, a composition comprising the substance and a tracer able to be introduced into and be determined in association with the subject; and determining whether the substance was administered to the subject by determining the tracer in association with the subject. - View Dependent Claims (2, 3, 6, 7, 10, 11, 13, 14, 15, 18, 39, 40, 41, 42, 45)
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4-5. -5. (canceled)
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8-9. -9. (canceled)
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12. (canceled)
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16-17. -17. (canceled)
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19-38. -38. (canceled)
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43-44. -44. (canceled)
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46. A method, comprising:
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administering a composition comprising a tracer and a substance to a subject; and determining activity of the substance within the subject by determining the tracer within the subject. - View Dependent Claims (47, 49, 53, 62)
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48. (canceled)
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50-52. -52. (canceled)
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54-56. -56. (canceled)
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58-61. -61. (canceled)
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63. A method, comprising;
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administering a composition comprising a tracer and a pharmaceutically acceptable carrier to a subject; and administering an indicator responsive to the tracer to the skin of the subject. - View Dependent Claims (65, 69, 70, 71, 72)
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64. (canceled)
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66-68. -68. (canceled)
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73. (canceled)
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74. A method, comprising:
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administering, to a subject, a composition comprising a tracer and a substance able to be introduced and be determined in the subject; and administering an indicator responsive to the tracer to the skin of the subject, the indicator able to change a property upon response to the tracer. - View Dependent Claims (75, 77, 78, 80)
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76. (canceled)
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79. (canceled)
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81-87. -87. (canceled)
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88. A method, comprising:
offering, to a subject, an ingestible composition comprising a tracer and an ingestible substance, and a dermally-applicable composition comprising an indicator able to change a visual property upon exposure to the tracer. - View Dependent Claims (90, 98)
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89. (canceled)
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91-97. -97. (canceled)
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99. (canceled)
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100. A method, comprising:
determining a substance within a subject by monitoring a tracer within the subject. - View Dependent Claims (101, 104, 105, 107)
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102-103. -103. (canceled)
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106. (canceled)
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108-111. -111. (canceled)
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112. A method, comprising:
determining an exogenous tracer within a subject indicative of a substance administered to the subject. - View Dependent Claims (113, 114, 115, 125, 126)
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116-122. -122. (canceled)
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124. (canceled)
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127. A kit, comprising;
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a composition comprising a tracer and a carrier containing the tracer; and a skin delivery device comprising an indicator responsive to the tracer. - View Dependent Claims (129, 131, 132)
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128. (canceled)
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130. (canceled)
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133. A kit, comprising;
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a composition comprising a tracer and a substance; and a skin delivery device comprising an indicator responsive to the tracer. - View Dependent Claims (134, 135, 136)
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137-140. -140. (canceled)
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141. A kit, comprising:
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a tracer; a substance; and instructions for administering the tracer and the substance to a subject, and determining the tracer within the subject. - View Dependent Claims (142, 144)
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143. (canceled)
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145-146. -146. (canceled)
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148. A method, comprising:
offering, to a subject, an ingestible composition comprising a tracer and an ingestible substance, and a device comprising an indicator able to change a visual property upon exposure to the tracer. - View Dependent Claims (149, 151, 152, 153, 154, 157)
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150. (canceled)
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155-156. -156. (canceled)
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158. (canceled)
Specification