BIOSENSOR DEVICE AND METHOD OF SEQUENCING BIOLOGICAL PARTICLES
First Claim
1. A biosensor device for sequencing biological particles, the biosensor device comprisingat least one substrate;
- a plurality of sensor active regions provided on each of the at least one substrate and each of the sensor active regions comprising a primer having a sequence being complementary to a part of a sequence of the biological particles for enabling generation of fragments having a sequence being inverse to a part of the sequence of the biological particles at the primer;
a determination unit adapted for individually determining a size of the fragments replicated at the primer of each of the plurality of sensor active regions, the fragment generation being terminated in the presence of replication terminating sequence units.
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Accused Products
Abstract
A biosensor device (100) for sequencing biological particles (102), the biosensor device (100) comprising at least one substrate (104), a plurality of sensor active regions (106) provided on each of the at least one substrate (104) and each comprising a primer (108) having a sequence being complementary to a part of a sequence of the biological particles (102) and enabling generation of fragments having a sequence being inverse to a part of the sequence of the biological particles (102) at the primer (108), and a determination unit (114) adapted for individually determining a size of the fragments generated at the primer (108) of each of the plurality of sensor active regions (106), the fragment replication being terminated in the presence of replication terminating sequence units (116 to 119).
82 Citations
20 Claims
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1. A biosensor device for sequencing biological particles, the biosensor device comprising
at least one substrate; -
a plurality of sensor active regions provided on each of the at least one substrate and each of the sensor active regions comprising a primer having a sequence being complementary to a part of a sequence of the biological particles for enabling generation of fragments having a sequence being inverse to a part of the sequence of the biological particles at the primer; a determination unit adapted for individually determining a size of the fragments replicated at the primer of each of the plurality of sensor active regions, the fragment generation being terminated in the presence of replication terminating sequence units. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19, 20)
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17. A method of sequencing biological particles, the method comprising
providing a plurality of sensor active regions on each of at least one substrate, each of the plurality of sensor active regions comprising a primer having a sequence being complementary to a part of a sequence of the biological particles and enabling generation of fragments having a sequence being inverse to a part of the sequence of the biological particles at the primer; individually determining a size of fragments generated at the primer of each of the plurality of sensor active regions, the fragment replication being terminated in the presence of replication terminating sequence units. - View Dependent Claims (18)
Specification