INTEGRATED PATIENT MANAGEMENT AND CONTROL SYSTEM FOR MEDICATION DELIVERY
First Claim
1. A system for determining a diagnostic result from a fluid medium comprising:
- a series of assay devices,a measurement device to provide diagnostic results,a storage device for said assay devices,an advancement mechanism said assay devices through a sample application area, anda mechanism for dispensing a fluid medium to an assay device.
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Accused Products
Abstract
An integrated patient monitoring and control system is provided which includes a closed-loop control system for monitoring and adjusting the heparin infusion rate for a patient. The system includes a processor which uses a dynamic patient model that is continuously adjusted based on the patient'"'"'s aPTT measurements to calculate an optimal heparin infusion rate to achieve an operator-input aPTT target range. The processor also includes a forecasting model to calculate the optimum sample time interval for measuring the patient'"'"'s aPTT to calculate a new infusion rate. An automated sampling system, which includes a storage device for storing a series of assay devices, an advancement mechanism for moving the assay devices to a sample area, and a measurement device for analyzing a sample dispensed on the assay, is provided. The sampling system is used to repeatedly measure the patient'"'"'s aPTT according to the sample time interval determined by the processor.
153 Citations
48 Claims
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1. A system for determining a diagnostic result from a fluid medium comprising:
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a series of assay devices, a measurement device to provide diagnostic results, a storage device for said assay devices, an advancement mechanism said assay devices through a sample application area, and a mechanism for dispensing a fluid medium to an assay device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system for storing assay devices used to measure a diagnostic result in a fluid medium comprising:
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a series of assay devices; a storage device for said assay devices; and an integrated waste area that contains materials to absorb a liquid component of a waste material. - View Dependent Claims (23, 24, 25, 26)
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18. A system for determining activated partial thromboplastin time (aPTT) in a fluid medium employing a device comprising
a cassette containing a set of assay devices, an aPTT measurement device, an advancement mechanism for advancing said assay devices through a sample application area, and a reservoir for collecting a liquid waste.
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27. A system for determining Prothrombin time (PT/INR) in a fluid medium employing a device comprising:
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a cassette containing a set of assay devices; a PT/INR measurement device; an advancement mechanism for advancing said assay device to a sample application area; and a reservoir for collecting a liquid waste.
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28. A method for determining the infusion rate for delivering heparin to a patient comprising the steps of:
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(a) obtaining a patient blood sample; (b) measuring the patient'"'"'s Activated Partial Thromboplastin Time (aPTT); (c) inputting the patient aPTT measurement into a processor; (d) inputting an aPTT target for the patient into the processor; and (e) using the processor to calculate a heparin infusion rate for the patient to achieve the target aPTT, the processor implementing a protocol including a dynamic patient model based on a pharmacodynamic model of heparin response that utilizes; (i) the patient'"'"'s past history of infusion rates and (ii) the current infusion rate to calculate the heparin infusion rate. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
monitoring the patient response to the heparin delivery, wherein the monitoring comprises taking a blood sample form the patient and measuring the patient'"'"'s aPTT according to a sampling frequency determined by the processor; adjusting the dynamic patient model to reflect the patient'"'"'s individualized heparin response; using the processor to calculate an updated heparin infusion rate based the revised protocol; and adjusting the heparin delivery to the updated infusion rate.
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42. A method for determining the sampling schedule for controlling the heparin delivery rate to a patient to maintain an optimal heparin delivery rate comprising the steps of:
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(a) obtaining a patient blood sample; (b) measuring the patient'"'"'s Activated Partial Thromboplastin Time (aPTT); (c) inputting the patient aPTT measurement into a processor; (d) inputting an aPTT target for the patient into the processor; and (e) using the processor to calculate a time interval for re-measuring the patient'"'"'s aPTT to maintain an optimal infusion rate for the patient, the processor implementing a protocol including a dynamic patient model based on a pharmacodynamic model of heparin response that utilizes; (i) the patient'"'"'s past history of infusion rates and (ii) the current infusion rate to calculate the optimal time interval for re-measuring the patient'"'"'s aPTT. - View Dependent Claims (43, 44, 45, 46, 47, 48)
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Specification