CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
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Accused Products
Abstract
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
66 Citations
41 Claims
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1-22. -22. (canceled)
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23. A pharmaceutical formulation for use in the treatment of an otic disease or condition formulated to provide to the inner ear of a patient in need thereof a therapeutically-effective, sustained-release amount of an agent that modulates the Atoh1 gene, the formulation comprising:
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between about 0.2% to about 20% by weight of the agent that modulates the Atoh1 gene or pharmaceutically acceptable prodrug or salt thereof; and a thermoreversible gel having a gelation temperature between about 19°
C. and about 40°
C. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for treating an otic disease or condition comprising administering to a patient in need thereof a sustained release pharmaceutical composition formulated to provide to the inner ear of a patient in need thereof a therapeutically-effective amount of an agent that modulates the Atoh1 gene, the formulation comprising:
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between about 0.2% to about 20% by weight of the agent that modulates the Atoh1 gene or pharmaceutically acceptable prodrug or salt thereof; and a thermoreversible gel having a gelation temperature between about 19°
C. and about 40°
C. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification