WIRELESS MONITORING BIO-DIAGNOSIS SYSTEM

• US 20100274101A1
• Filed: 09/10/2009
• Published: 10/28/2010
• Est. Priority Date: 04/24/2009
• Status: Abandoned Application

• Current Assignee: National Taiwan University (Government of The Republic of China)
• Original Assignee: National Taiwan University (Government of The Republic of China)
• Inventors: Chen, Chern-Lin, Lei, U, Yang, Lung-Jieh, Lin, Shi-Ming, Jaw, Fu-Shan, Lee, Chih-Kung, Lin, Phone, Lu, Shey-Shi, Yang, Yao-Joe, Yen, Jia-Yush, Huang, Long-Sun, Shih, Wen-Pin, Lin, Chii-Wann, Wu, Kuang-Chong, Chiu, Nan-Fu, Lee, Shih-Yuan
• Application Number:
  US12/556,675
• Publication Number:
  US 20100274101A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C12Q 1/26 involving oxidoreductase
• CPC Class Codes: C12Q 1/32 involving dehydrogenase
• CPC Class Codes: G01N 2800/32 Cardiovascular disorders
• CPC Class Codes: G01N 33/6893 related to diseases not provided for elsewhere

Abstract

A MEMS wireless monitoring bio-diagnosis system includes an implantable biosensor system chip, a surface transmitter and an external monitor center. The implantable biosensor system chip contains a biosensor for a cardio-vascular indicator and a wireless transmitter to deliver detected bio-signal data. With the MEMS wireless monitoring bio-diagnosis system, the bio-signal data can be monitored effectively and transmitted to a remote medical unit.

Claims

1. A wireless monitoring bio-diagnosis system, comprising:

one or more implantable biosensor system chips;

a surface transmitter; and

an external monitor center;

wherein the implantable biosensor system chip is connected to the surface

transmitter via a wireless network and connected to the external monitor

center via an external network.

2. The wireless monitoring bio-diagnosis system of claim 1, further comprising:

a biocompatible package;

a biosensor; and

a wireless transmitter;

wherein the biosensor and the wireless transmitter are wrapped inside the

biocompatible package.

3. The wireless monitoring bio-diagnosis system of claim 2, wherein the biocompatible package is made of polyurethane, polyethylene, polymethylmethacrylate, polyester, poly tetra fluoro ethylene, polydimethylsiloxane, poly tetramethylene succinate, polymethylmethacrylate or a polymer with a good biocompatibility.

4. The wireless monitoring bio-diagnosis system of claim 2, wherein the biosensor comprises a dielectrophoreis electrode and an electrochemical detection electrode for driving a fluid and separating blood.

5. The wireless monitoring bio-diagnosis system of claim 2, wherein the biosensor comprises an inlet and an outlet for circulating blood.

6. The wireless monitoring bio-diagnosis system of claim 2, wherein the wireless transmitter comprises a radio frequency (RF) power device.

7. The wireless monitoring bio-diagnosis system of claim 1, wherein the implantable biosensor system chip monitors a heartbeat, a blood sugar, an enzyme concentration, a protein concentration or any other physiological signal.

8. The wireless monitoring bio-diagnosis system of claim 7, wherein the implantable biosensor system chip monitors an enzyme or a protein indicating a cardiovascular disease.

9. The wireless monitoring bio-diagnosis system of claim 8, wherein the enzyme is lactate dehydrogenase or glucose oxidase.

10. The wireless monitoring bio-diagnosis system of claim 8, wherein the protein is C-reactive protein or S-100 protein.

11. A manufacturing method of an implantable biosensor system chip of claim 2, comprising the steps of:

cleaning a glass substrate;

coating a thin film on the glass substrate by thin film deposition;

using a mask to produce a pattern by photolithography; and

developing the pattern by photoresist stripping.