Method and System for Providing Basal Profile Modification in Analyte Monitoring and Management Systems

• US 20100274220A1
• Filed: 07/10/2010
• Published: 10/28/2010
• Est. Priority Date: 11/04/2005
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Sloan, Mark K., Hayter, Gary
• Granted Patent: US 8,585,591 B2
• Time in Patent Office: Days
• US Class Current: 604/504
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed.

Claims

1. A method comprising:

administering medication to a patient according to a medication delivery profile during a predetermined time period, the predetermined time period including a plurality of time of day segments;

monitoring, using a sensor, an analyte level of the patient for the predetermined time period;

determining, using a processing unit, a frequency of the analyte level deviating from a predetermined level during one or more of the plurality of time of day segments; and

determining, using the processing unit, a modification of the medication delivery profile for the one or more of the plurality of time of day segments in which the frequency of the analyte level deviating from the predetermined level exceeds a predetermined threshold.

2. The method of claim 1 further comprising providing a recommendation to one or both of the patient and a health care provider for the modification of the medication delivery profile.

3. The method of claim 2 wherein the recommendation is provided visually and/or audibly.

4. The method of claim 1 further comprising executing the determined modification of the medication delivery profile.

5. The method of claim 4 wherein the medication is insulin, the analyte monitored is glucose, and the executing the determined modification of the medication delivery profile includes one or more of eliminating extreme glucose excursions, automating or semi-automating routine or regular bolus dosing, and adjusting the mean glucose value.

6. The method of claim 4 wherein the executing the determined modification of the medication delivery profile includes modifying a currently running medication delivery profile prior to its completion.

7. The method of claim 1 further comprising storing the determined modification to the mediation delivery profile.

8. The method of claim 1 wherein the medication delivery profile is based at least in part on the time of day and patient specific parameters.

9. The method of claim 8 wherein the administered medication is insulin, the monitored analyte is glucose, and the patient specific parameters include one or more of the patient'"'"'s insulin sensitivity, the type of insulin being administered, patient activities during the predetermined time period and patient carbohydrate intake during the predetermined time period.

10. The method of claim 1 wherein medication delivery profile is based at least in part on a frequency of bolus dosing of the medication during the predetermined time period and the level of medication on board.

11. An apparatus comprising:

a medication administration device for administering medication to a patient according to a medication delivery profile during a predetermined time period, the predetermined time period including a plurality of time of day segments;

a sensor configured to monitor an analyte level of the patient for a predetermined time period; and

a processing unit configured to determine a frequency of the analyte level deviating from a predetermined level during one or more of the plurality of time of day segments and configured to determine a modification of the medication delivery profile for the one or more of the plurality of time of day segments in which the frequency of the analyte level deviating from the predetermined level exceeds a predetermined threshold.

12. The apparatus of claim 11 wherein the processing unit is further configured to output a visual and/or audible recommendation to one or both of the patient and a health care provider for the modification of the medication delivery profile.

13. The apparatus of claim 11 wherein the medication administration device is configured to execute the determined modification of the medication delivery profile.

14. The apparatus of claim 13 further comprising a data storage unit operatively coupled to the processing unit, the processing unit further configured to store data and retrieve stored data from the data storage unit, wherein the data is associated with the monitored analyte level of the patient.

15. The apparatus of claim 11 wherein the medication delivery profile is based at least in part on the time of day and patient specific parameters.

16. The apparatus of claim 15 wherein the medication administration device is an insulin pump, the sensor is a glucose sensor, and the patient specific parameters include one or more of the patient'"'"'s insulin sensitivity, the type of insulin being administered, patient activities during the predetermined time period and patient carbohydrate intake during the predetermined time period.

17. The apparatus of claim 11 wherein medication delivery profile is based at least in part on a frequency of bolus dosing of the medication during the predetermined time period and the level of medication on board.

18. The apparatus of claim 11 wherein the medication administration device is an insulin pump and the sensor is glucose sensor.