Cartilage particle tissue mixtures optionally combined with a cancellous construct
First Claim
1. A sustained release composition, comprising lyophilized freeze-milled cartilage particles having a size no greater than 1 mm and an active growth factor exogenous to said cartilage particles, said growth factor being incorporated into said composition such that said growth factor is released substantially continuously over a prolonged period of time.
2 Assignments
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Accused Products
Abstract
Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.
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Citations
44 Claims
- 1. A sustained release composition, comprising lyophilized freeze-milled cartilage particles having a size no greater than 1 mm and an active growth factor exogenous to said cartilage particles, said growth factor being incorporated into said composition such that said growth factor is released substantially continuously over a prolonged period of time.
- 40. A method of repairing a defect in cartilage in a subject in need thereof, comprising the step of placing, in a defect site, a sustained release composition including lyophilized freeze-milled cartilage particles having a size no greater than 1 mm and an active growth factor exogenous to said cartilage particles, said growth factor being incorporated into said composition such that said growth factor is released substantially continuously over a prolonged period of time.
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44. A composition, comprising lyophilized freeze-milled cartilage particles having a size no greater than 1 mm and a biocompatible carrier including freeze-dried fibrin.
Specification