Topical Therapeutic Delivery System
First Claim
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1. An oil-in-water emulsion topical delivery system comprising (i) an oil phase;
- (ii) an aqueous phase;
(iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition;
(iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group;
(v) a non-ionic emulsifier having an HLB of from about 7 to about 10; and
(vi) at least one skin-supporting or dermatopharmaceutically active agent.
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Abstract
The present invention relates to an oil-in-water emulsion topical delivery system comprising an oil phase; an aqueous phase; phenoxyethanol; an effective exfoliatingamount of a hydrophobic hydroxycarboxylic acid; a non-ionic emulsifier having an HLB of from about 7 to about 10; and at least one skin-supporting ordermatopharmaceutically active agent.
94 Citations
106 Claims
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1. An oil-in-water emulsion topical delivery system comprising (i) an oil phase;
- (ii) an aqueous phase;
(iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition;
(iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group;
(v) a non-ionic emulsifier having an HLB of from about 7 to about 10; and
(vi) at least one skin-supporting or dermatopharmaceutically active agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 22, 23, 28, 102, 105)
- (ii) an aqueous phase;
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11. (canceled)
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17-21. -21. (canceled)
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24-27. -27. (canceled)
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29-101. -101. (canceled)
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103-104. -104. (canceled)
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106-116. -116. (canceled)
Specification