REGULATION OF MAMMALIAN KERATINOUS TISSUE USING HEXAMIDINE COMPOSITIONS

• US 20100278765A1
• Filed: 07/13/2010
• Published: 11/04/2010
• Est. Priority Date: 03/04/2003
• Status: Abandoned Application

• Current Assignee: Donald Lynn Bissett
• Original Assignee: Donald Lynn Bissett
• Inventors: Bissett, Donald Lynn
• Application Number:
  US12/835,244
• Publication Number:
  US 20100278765A1
• Time in Patent Office: Days
• US Class Current: 424/60
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/606 Nucleosides; Nucleotides; Nucleic acids
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/06 for countering cellulitis
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising:

• • a) a safe and effective amount of a hexamidine compound selected from the group consisting of hexamidine, its salts, and derivatives;
  • b) a safe and effective amount of one or more skin care active selected from the group consisting of sugar amine, vitamin B₃, retinoid, peptide, phytosterol, butylated hydroxytoluene and butylated hydroxyanisole, their derivatives, and combinations thereof; and
  • c) a dermatologically acceptable carrier for the hexamidine and the skin care active.

In additional embodiments, the above composition is suitable for preventing, retarding, and/or treating dark under-eye circles, puffy eyes, sagging, sallowness as well as spider vessels and/or red blotchiness of skin, promoting skin desquamation, exfoliation, and/or turnover, regulating and/or reducing pore size appearance, preventing/retarding tanning, regulating oily/shiny appearance, preventing, retarding, and/or treating hyperpigmentation in mammalian skin, preventing, retarding, and/or treating itchiness of mammalian skin, preventing, retarding, and/or treating dryness of skin, preventing, retarding, and/or treating fine lines and wrinkles, preventing, retarding, and/or treating skin atrophy of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing, retarding, and/or treating the appearance of cellulite in mammalian skin.

Claims

1. A skin care composition comprising:

a) from about 0.02% to about 2.5% of a hexamidine compound;

b) from about 1% to about 5% of a vitamin B₃ compound; and

c) a dermatologically acceptable carrier for the hexamidine and the skin care active, wherein said carrier is an emulsion.

2. The skin care composition of claim 1 wherein the hexamidine compound comprises hexamidine diisethionate.

3. The skin care composition of claim 1 wherein said composition comprises from about 0.001% to about 10%, by weight, of an additional skin care active selected from the group consisting of desquamatory actives, anti-acne actives, wrinkle repair actives, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, and combinations thereof.

4. The skin care composition of claim 1 wherein the emulsion is selected from the group consisting of water-in-oil emulsions, oil-in-water emulsions, water-in-silicone emulsions, and combinations thereof.

5. The skin care composition of claim 1 further comprising a sugar amine.

6. The skin care composition of claim 5 wherein said sugar amine is N-acetyl glucosamine and said vitamin B3 compound is niacinamide.

7. The skin care composition of claim 1 wherein said vitamin B₃ compound comprises niacinamide.

8. The skin care composition of claim 1 further comprising ascorbyl glucoside.

9. The skin care composition of claim 1 further comprising a retinoid.

10. The skin care composition of claim 1 further comprising a peptide.

11. The skin care composition of claim 10 wherein the peptide is selected from a group consisting of dipeptides, tripeptides, tetrapeptides, and pentapeptides.

12. The skin care composition of claim 10 wherein the peptide is carnosine.

13. The skin care composition of claim 1 further comprising a phytosterol.

14. The skin care composition of claim 1 further comprising a compound according to formula (I):

15. A method of regulating the condition of mammalian keratinous tissue, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

16. A method of preventing, retarding, and/or treating hyperpigmentation, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

17. A method of preventing, retarding, and/or treating the appearance of fine lines and/or wrinkles in mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

18. A method of thickening the skin and/or preventing, retarding, and/or treating skin atrophy of a mammal, said method comprising the step of topically applying to the skin of a mammal needing such treatment the composition of claim 1.

19. A method of preventing, retarding, and/or treating the appearance of spider vessels and/or red blotchiness on mammalian skin, said method comprising the step of topically applying to the skin of a mammal needing such treatment the composition of claim 1.

20. A method of preventing, retarding, and/or treating the appearance of dark, under-eye circles and/or puffy eyes, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

21. A method of preventing, retarding, and/or treating sallowness of mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

22. A method of preventing and/or retarding tanning of mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

23. A method of desquamating, exfoliating, and/or increasing turnover in mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

24. A method of regulating and/or reducing the size of pores in mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

25. A method of regulating the oily and/or shiny appearance of mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment the composition of claim 1.

26. A method of preventing, retarding, and/or treating sagging of mammalian skin, said method comprising the step of topically applying to the skin of a mammal needing such treatment the composition of claim 1.

27. A method of softening and/or smoothing lips, hair and nails of a mammal, said method comprising the step of topically applying to the lips, hair, and nails of a mammal needing such treatment the composition of claim 1.

28. A method of preventing, retarding, and/or treating itch of mammalian skin, said method comprising the step of topically applying to the skin of a mammal needing such treatments the composition of claim 1.

29. A method of preventing, retarding, and/or treating skin dryness in mammalian skin, said method comprising the step of topically applying to the skin of a mammal in need of such treatment, the composition of claim 1.

30. A skin care composition comprising:

a) from about 0.02% to about 2.5% of a hexamidine compound;

b) from about 1% to about 5% of a vitamin B₃ compound;

c) a panthenol compound; and

d) a dermatologically acceptable carrier, wherein said carrier is an emulsion.

31. The skin care composition of claim 30 further comprising a vitamin E compound.

32. The skin care composition of claim 31 wherein said vitamin E compound comprises tocopherol acetate.

33. The skin care composition of claim 30 wherein the anti-cellulite agent is caffeine.

34. A skin care composition comprising:

a) from about 0.02% to about 1% of hexamidine diisethionate;

b) from about 1% to about 5% of niacinamide; and

c) a dermatologically acceptable carrier, wherein said carrier is an emulsion.

35. The skin care composition of claim 34 wherein said composition comprises from about 0.001% to about 10%, by weight, of an additional skin care active selected from the group consisting of desquamatory actives, anti-acne actives, wrinkle repair actives, anti-oxidants, radical scavengers, chelators, anti-inflammatory agents, topical anesthetics, tanning actives, skin lightening agents, anti-cellulite agents, flavonoids, antimicrobial actives, antifungal actives, sunscreen actives, conditioning agents, and combinations thereof.

36. The skin care composition of claim 34 wherein the emulsion is selected from the group consisting of water-in-oil emulsions, oil-in-water emulsions, water-in-silicone emulsions, and combinations thereof.

37. The skin care composition of claim 34 further comprising a sugar amine.

38. The skin care composition of claim 37 wherein said sugar amine is N-acetyl glucosamine.

39. The skin care composition of claim 34 further comprising a retinoid.

40. The skin care composition of claim 34 further comprising a peptide.

44. The skin care composition of claim 34 further comprising a phytosterol.

41. The skin care composition of claim 41 wherein the peptide is selected from a group consisting of dipeptides, tripeptides, tetrapeptides, pentapeptides, and combination thereof.

43. The skin care composition of claim 41 wherein the peptide is a dipeptide and a pentapeptide.

42. The skin care composition of claim 42 wherein the peptide is carnosine.