USE OF PROTEIN MICROBEADS IN COSMETICS

• US 20100278882A1
• Filed: 01/19/2007
• Published: 11/04/2010
• Est. Priority Date: 01/20/2006
• Status: Abandoned Application

• Current Assignee: BASF SE
• Original Assignee: BASF SE
• Inventors: Hümmerich, Daniel, Scheibel, Thomas, Liebmann, Burghard, Fehr, Marcus, Ptock, Arne
• Application Number:
  US12/161,352
• Publication Number:
  US 20100278882A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

Use of protein microbeads in cosmetics

Claims

1. (canceled)

2. (canceled)

3. (canceled)

4. (canceled)

5. (canceled)

6. (canceled)

7. (canceled)

8. (canceled)

9. (canceled)

10. A method for preparing a cosmetic comprising incorporating a protein microbead into the cosmetic.

11. The method of claim 10, wherein the protein microbead comprises silk protein.

12. The method of claim 10, wherein the protein microbead is produced from a predominantly intrinsically unfolded protein.

13. The method of claim 12, wherein more than 50% of amino acid radicals comprising the predominantly intrinsically unfolded protein have a value of >

0.5 calculated by an IUpred algorithm.

14. The method of claim 13, wherein the protein microbead comprises a coupling a protein and an effector molecule.

15. The method of claim 14, wherein the effector molecule is a UV photoprotective filter.

16. The method of claim 12, wherein the predominantly intrinsically unfolded protein is a C16 spider silk protein.

17. The method of claim 12, wherein the protein microbead is produced by a method comprising the steps of:

(1) dissolving a protein in a solvent, (2) inducing phase separation in the emulsified solvent phase and protein-rich phase through an additive, (3) curing the protein-rich phase, optionally, by adding a crosslinker, (4) isolating and, optionally, purifying the protein microbead of step (3).

18. The method of claim 10, wherein the cosmetic is a skin cosmetic.

19. A cosmetic composition comprising a protein microbead and an effector molecule.

20. The cosmetic composition of claim 19, wherein the effector molecule is a 1 UV photoprotective filter.

21. The cosmetic composition of claim 20, wherein the UV photoprotective filter is a UV-A filter.

22. The cosmetic composition of claim 20, wherein the UV photoprotective filter is a UV-B filter.

23. The cosmetic composition of claim 19, wherein the protein microbead is produced from a predominantly intrinsically unfolded protein.

24. The cosmetic composition of claim 23, wherein more than 50% of amino acid radicals comprising the predominantly intrinsically unfolded protein have a value of >

0.5 calculated according to an IUpred algorithm.

25. The cosmetic composition of claim 19, wherein the protein microbead is produced from a predominantly intrinsically unfolded protein, wherein more than 50% of amino acid radicals comprising the predominantly intrinsically unfolded protein have a value of >

0.5 calculated according to an IUpred algorithm, and the effector molecule is a UV photoprotective filter.

26. The cosmetic composition of claim 19, wherein the protein microbead is produced from a C16 spider silk protein, and the effector molecule is a UV photoprotective filter.

27. The cosmetic composition of claim 19, wherein the cosmetic is a skin cosmetic.