INTRAOCULAR BIOACTIVE AGENT DELIVERY SYSTEM WITH MOLECULAR PARTITIONING SYSTEM
First Claim
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1. An intraocular implant for treating an ocular condition, the implant comprising:
- a molecular partitioning system comprising a poly(D,L-lactide) phase having a first inherent viscosity;
a poly(D,L-lactide-co-glycolide) phase having a second inherent viscosity; and
at least one therapeutic bioactive agent;
wherein said first mean viscosity is at least about four times greater than said second mean viscosity, and wherein said molecular partitioning system provides controlled release of said at least one therapeutic bioactive agent from said intraocular implant.
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Abstract
The present disclosure generally provides intraocular implants including at least one therapeutic bioactive agent and a molecular partitioning system. The molecular partitioning system comprises at least two phases wherein the first phase has an inherent viscosity equal or greater than the inherent viscosity of a second phase. The molecular partitioning system allows the intraocular implants to controllably release the at least one therapeutic bioactive agent into the surrounding tissues once implanted.
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Citations
20 Claims
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1. An intraocular implant for treating an ocular condition, the implant comprising:
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a molecular partitioning system comprising a poly(D,L-lactide) phase having a first inherent viscosity;
a poly(D,L-lactide-co-glycolide) phase having a second inherent viscosity; and
at least one therapeutic bioactive agent;wherein said first mean viscosity is at least about four times greater than said second mean viscosity, and wherein said molecular partitioning system provides controlled release of said at least one therapeutic bioactive agent from said intraocular implant. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A process for making an intraocular implant having a molecular partition system comprising:
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dissolving a poly(D,L-lactide) polymer having a first mean viscosity;
a poly(D,L-lactide-co-glycolide) polymer having a second mean viscosity; and
at least one therapeutic bioactive agent in a solvent thereby forming a mixture;casting said mixture; evaporating said solvent thereby forming a polymeric film comprising said molecular partitioning system, said molecular partitioning system comprising a poly(D,L-lactide) phase having said first mean viscosity and a poly(D,L-lactide-co-glycolide) phase having said second mean viscosity; and extruding said polymer film thereby making said intraocular implant, wherein said first mean viscosity is at least about four times greater than said second mean viscosity and said molecular partitioning system provides controlled release of said at least one therapeutic bioactive agent from said intraocular implant. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method of treating an ocular condition comprising the steps of:
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(a) selecting a patient with an ocular condition in need of treatment; (b) providing an intraocular implant comprising a molecular partitioning system comprising a poly(D,L-lactide) phase having a first mean viscosity;
a poly(D,L-lactide-co-glycolide) phase having a second mean viscosity; and
at least one therapeutic bioactive agent, wherein said first mean viscosity is at least about four times greater than said second mean viscosity, and wherein said molecular partitioning system provides controlled release of said at least one therapeutic bioactive agent from said intraocular implant;(c) inserting said intraocular implant into a region of an eye; and (d) treating said ocular condition. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A process of making an intraocular implant having a molecular partitioning system comprising:
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dissolving a poly(D,L-lactide) polymer having a mean viscosity between about 1.3 and about 1.7 dl/g ;
a poly(D,L-lactide-co-glycolide) polymer having a mean viscosity between about 0.32 and about 0.44 dl/g; and
at least one bioactive agent in dichloromethane thereby forming a mixture;casting said mixture; evaporating said dichloromethane thereby forming a polymer film comprising said molecular partitioning system having a poly(D,L-lactide) phase and a poly(D,L-lactide-co-glycolide) phase; and extruding said polymeric film into rod shaped structures at a temperature of about 90°
C. thereby making said intraocular implant,wherein said molecular partitioning system provides controlled release of said at least one bioactive agent from said intraocular implant. - View Dependent Claims (20)
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Specification