MOISTURIZING ANTIMICROBIAL COMPOSITION

• US 20100278906A1
• Filed: 04/30/2010
• Published: 11/04/2010
• Est. Priority Date: 05/01/2009
• Status: Active Grant

• Current Assignee: Gold Bond Company LLC
• Original Assignee: Chattem Incorporated (Sanofi )
• Inventors: Czerwinkski, Joe, Sondgeroth, Jason
• Granted Patent: US 8,388,991 B2
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/463 containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

An antimicrobial moisturizing composition includes benzethonium chloride or benzalkonium chloride, a non-benzyl cationic surfactant, and an aqueous carrier. The composition of the present invention provides a significant and unexpected reduction of irritation, inflammation, dryness and/or redness, all issues associated with known alcohol-based skin disinfectants. In particular, the present invention provides a stable, aesthetically-pleasing, long-lasting, and moisturizing antimicrobial composition that is substantially free of ethanol, polysorbates, and anionic compounds that are known to inhibit the activity of benzethonium chloride or benzalkonium chloride.

Claims

1. A moisturizing antimicrobial composition comprising:

from about 0.05% to about 4.0% by weight of a compound selected from the group of benzethonium chloride, benzalkonium chloride, and mixtures thereof;

from about 0.01% to about 10.0% by weight of a cationic surfactant having a molar mass of less than about 800 g/mol; and

from about 30% to about 90% by weight of an aqueous carrier.

2. The moisturizing composition of claim 1 wherein said composition comprises from about 0.1% to 0.5% by weight of a compound selected from the group of benzethonium chloride, benzalkonium chloride, and mixtures thereof;

3. The moisturizing composition of claim 1, wherein said cationic surfactant is a non-benzyl cationic surfactant.

4. The moisturizing composition of claim 3, wherein said non-benzyl cationic surfactant is a fatty quaternary amine selected from the group consisting of preferably an alkyl ammonium chloride, dimethyl dialkyl ammonium chloride, alkyl ammonium methosulfate, alkyl ammonium chloride, derivatives and combinations thereof.

5. The moisturizing composition of claim 3, wherein said non-benzyl cationic surfactant is selected from the group consisting of behentrimonium methosulfate, distearyl dimonium chloride, derivatives and combinations thereof.

6. The moisturizing composition of claim 3, wherein said non-benzyl, cationic surfactant is selected from the group consisting of laurtrimonium chloride, lauralkonium chloride, olealkonium chloride, dilauryldimonium chloride, cetalkonium chloride, dicetyldimonium chloride, laurylpyridinium chloride, cetylpyridinium chloride, soyatrimonium chloride;

cetrimonium chloride;

mytrimonium chloride, stearamidoethylethanolamine, stearamidoethyldiethanolamine, isostearamidopropylmorpholine, stearamidopropylmorpholine, stearamidopropyldimethylamine, diethylaminoethyl stearamide, dimethylaminopropyl myristamine, cetethyldimonium bromide;

cetrimonium tosylate;

stearalkonium chloride;

cetrimonium bromide;

cetethylmorpholinium ethosulfate;

behenalkonium chloride;

behentrimonium chloride;

mytrimonium bromide; and

combinations thereof.

7. The moisturizing composition of claim 3 wherein said non-benzyl cationic surfactant is an acid-neutralized amidoamine selected from the group consisting of an alkyl amidopropyl dimethylamine, alkyl amidoethylethanolamine, iso alkyl amidoproylmorpholine, alkyl amidopropylmorpholine, alkyl amidopropyldimethylamine and combinations thereof.

8. The moisturizing composition of claim 1, wherein said cationic surfactant has a molar mass of greater than about 800 g/mol.

9. The moisturizing composition of claim 8, wherein said cationic surfactant is a polyacrylate-1 crosspolymer.

10. The composition of claim 1, wherein the composition has a form selected from the group consisting of emulsions, creams, lotions, ointments, serums, liquids, lacquers, gels, sprays, exfoliating particulates, cleansing agents, cosmetics agents, bath additives, oils, nanosized particulates or liposomes, fragrances, powders, muds, masks and combinations thereof.

11. The composition of claim 1, further comprising from about 0.0001% to about 99.0% by weight of one or more alcohols.

12. The composition of claim 1, further comprising from about 0.0001% to about 99.0% by weight of a component selected from the group consisting of cosmeceuticals, anti-aging formulations, rejuvenating therapies, antioxidant therapies, anti-inflammatory agents, pharmaceuticals, and combinations thereof.

13. The composition of claim 1, further comprising from about 0.0001% to about 99.0% by weight of a component selected from the group consisting of preservatives, excipients, gelling agents, fragrances, buffers, binders, emulsifiers, solvents, electrolytes, sebum-absorbing polymers and other polymers, essential oils, botanical soothing agents, moisturizing beads, silicone skin conditioning agents and emollients, sunblocking and sunscreening agents, physical exfoliating particles, liposomes, chelating agents, and combinations thereof.

14. The composition of claim 1, further comprising from about 0.0001% to about 99.0% by weight of a component selected from the group consisting of vitamins, amino acids, salts thereof, derivatives thereof, and combinations thereof.

15. The composition of claim 1, further comprising from about 0.0001% to about 99.0% by weight of a pigment material selected from the group consisting of inorganic, nitroso, monoazo, disazo, carotenoid, triphenyl methane, triaryl methane, xanthene, quinoline, oxazine, azine, anthraquinone, indigoid, thionindigoid, quinacridone, phthalocianine, botanical and natural colors, and combinations thereof.

16. The composition of claim 1, wherein said composition has a viscosity of from about 10,000 to about 1,000,000 centipoise.

17. The composition of claim 1, wherein said composition is substantially free of polysorbates.

18. The composition of claim 1, wherein said composition is substantially free of ethanol.

19. The composition of claim 1, wherein said composition is substantially free of anionic compounds.

20. A moisturizing antimicrobial composition comprising:

from about 0.01% to 90% purified water;

from about 0.01% to 5.0% of a compound selected from the group of benzethonium chloride, benzalkonium chloride, and combinations thereof;

from about 0.01% to 20% potassium hydroxide;

from about 0.01% to 20% EDTA acid;

from about 0.01% to 20% potassium chloride;

from about 0.01% to 20% methylparaben;

from about 0.01% to 20% propylparaben;

from about 0.01% to 20% dimethicone;

from about 0.01% to 20% distearyldimonium chloride;

from about 0.01% to 20% cocamidopropyle PG-dimonium chloride phosphate;

from about 0.01% to 20% glyceryl laurate;

from about 0.01% to 20% behentrimonium methosulfate and cetyl alcohol;

from about 0.01% to 20% steareth-21; and

from about 0.01% to 20% cetyl alcohol.