PREPARATION FOR RESTENOSIS PREVENTION
4 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
119 Citations
37 Claims
-
1-15. -15. (canceled)
-
16. A method for making a drug-coated angioplasty catheter, comprising:
applying a solution of a lipophilic drug directly to the surface of a balloon wall of a balloon of the angioplasty catheter and drying the solution to form a coating of the lipophilic drug directly on the balloon wall to provide an outermost surface over the balloon, and wherein the coating is free from any time release material for the drug. - View Dependent Claims (17, 18, 19, 20, 37)
-
21. A method for making a drug-coated angioplasty device, comprising:
applying a solution of a lipophilic drug directly to a surface of an angioplasty device and drying the solution to form a coating of the lipophilic drug directly on the surface of the angioplasty device to provide an outermost surface over the angioplasty device, and wherein the coating is free from any time release material for the drug. - View Dependent Claims (22, 23, 24, 25, 26)
-
27. A method for making an angioplasty device useful for applying a lipophilic drug to a wall of a vascular vessel of a patient, the angioplasty device having an outermost surface for contact with the wall of the vascular vessel, the method comprising:
-
processing an angioplasty device so as to be suitable for insertion into a patient to perform an angioplasty, wherein the processed angioplasty device has an outermost coating comprising a lipophilic drug, the outermost coating positioned on a portion of the device that contacts the wall of the vascular vessel upon conduct of an angioplasty procedure with the angioplasty device, and the outermost coating being free from any time release material for the drug; wherein said processing includes applying an amount of the lipophilic drug directly to a base material of the device portion to form said outermost coating. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
-
-
35. A method for making a drug-coated angioplasty catheter, comprising:
applying a solution of a lipophilic drug directly to the surface of a balloon wall of a balloon of the angioplasty catheter and drying the solution to form a coating of the lipophilic drug directly on the balloon wall to provide an outermost surface over the balloon, and wherein the coating is free from any containment material for the drug.
-
36. A method for making a drug-coated angioplasty device, comprising:
applying a solution of a lipophilic drug directly to the surface of a polymeric balloon wall of a balloon of an angioplasty device and drying the solution to form a coating of the lipophilic drug directly on the polymeric balloon wall to provide an outermost surface over the balloon, and wherein the coating is free from any containment material for the drug.
Specification