HPTS-MONO AND BIS CYS-MA POLYMERIZABLE FLUORESCENT DYES FOR USE IN ANALYTE SENSORS

• US 20100279424A1
• Filed: 06/03/2010
• Published: 11/04/2010
• Est. Priority Date: 08/06/2007
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: GluMetrics, Inc.
• Inventors: SURI, JEFF T.
• Granted Patent: US 8,202,731 B2
• Time in Patent Office: Days
• US Class Current: 436/95
• CPC Class Codes: C09B 57/001 Pyrene dyes
• CPC Class Codes: C09B 69/109 containing other specific dyes
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.

Claims

1. The compound:

2. A method of making the compound of claim 1 comprising the steps of:

3. A hydrogel comprising a compound of claim 1.

4. A glucose sensor comprising a compound of claim 1.

5. The glucose sensor of claim 4, further comprising a quencher moiety comprising boronic acid.

6. The glucose sensor of claim 5, wherein said quencher moiety comprising boronic acid is 3,3′

-oBBV;

7. A glucose sensor comprising a hydrogel of claim 3.

8. A glucose sensor of claim 7 wherein the hydrogel further comprises a quencher moiety comprising boronic acid.

9. A glucose sensor of claim 8, wherein said quencher moiety comprising boronic acid is 3,3′

-oBBV.