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ASSAY METHOD FOR ALZHEIMER'S DISEASE

  • US 20100279433A1
  • Filed: 07/12/2010
  • Published: 11/04/2010
  • Est. Priority Date: 08/17/2001
  • Status: Active Grant
First Claim
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1. A method to diagnose preclinical or clinical Alzheimer'"'"'s disease in a subject, which method comprises administering to said subject an amount of an antibody which specifically binds an epitope contained within positions 13-28 of Aβ

  • or an antibody that sequesters Aβ

    peptide from its bound, circulating form in the blood and alters clearance of soluble and bound forms of Aβ

    in the central nervous system in plasma;

    effective to alter the levels of circulating Aβ

    peptides in the blood of said subject when said subject is in a preclinical or clinical stage of Alzheimer'"'"'s disease, followed by measuring the level of, Aβ

    40, Aβ

    42, or the ratio of Aβ

    40/Aβ

    42 in the blood of said subject at a time interval after said administering; and

    comparing the level of Aβ

    40, Aβ

    42, or the ratio of Aβ

    40/Aβ

    42 in said subject with a control value of said levels, wherein differing levels of Aβ

    40, Aβ

    42 or Aβ

    40/Aβ

    42 ratio in said subject as compared to control levels or ratio identifies said subject as in a preclinical or clinical stage of Alzheimer'"'"'s disease.

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