RECEPTOR TARGETED OLIGONUCLEOTIDES
First Claim
1. A composition for delivering an oligonucleotide to a target cell through endocytosis, wherein the composition comprises a conjugate comprising one or more ligand groups capable of mediating receptor endocytosis, one or more oligonucleotide groups each comprising an oligonucleotide, and a carrier macromolecule, wherein each of the ligand groups and each of the oligonucleotide groups are attached to the carrier macromolecule.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are oligonucleotide conjugates that include ligands that target cell receptors that mediate endocytosis. The ligands can include peptides and small molecules. The conjugates can include carrier macromolecules to which the ligands and oligonucleotides are attached, or conjugates where an oligonucleotide is attached to a ligand in the absence of a carrier macromolecule. The oligonucleotides can include therapeutic oligonucleotides, such as siRNA, antisense RNA and miRNA. The ligand can be an RGD peptide. Also disclosed herein are methods of delivering the conjugates to cells in subjects.
-
Citations
45 Claims
- 1. A composition for delivering an oligonucleotide to a target cell through endocytosis, wherein the composition comprises a conjugate comprising one or more ligand groups capable of mediating receptor endocytosis, one or more oligonucleotide groups each comprising an oligonucleotide, and a carrier macromolecule, wherein each of the ligand groups and each of the oligonucleotide groups are attached to the carrier macromolecule.
-
14. (canceled)
-
23-31. -31. (canceled)
-
38. (canceled)
-
45-50. -50. (canceled)
Specification