COMPOSITIONS OF HUMAN LIPIDS AND METHODS OF MAKING AND USING SAME

• US 20100280115A1
• Filed: 12/10/2007
• Published: 11/04/2010
• Est. Priority Date: 12/08/2006
• Status: Active Grant

• Current Assignee: Prolacta Bioscience Inc.
• Original Assignee: Prolacta Bioscience Inc.
• Inventors: Medo, Elena M., Eaker, Scott
• Granted Patent: US 8,377,445 B2
• Time in Patent Office: Days
• US Class Current: 514/560
• CPC Class Codes: A23C 9/206 Colostrum; Human milk
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/32 having an effect on the health of the digestive tract
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2300/34 Membrane process
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/06 Antianaemics

Abstract

The disclosure features methods of making compositions that include a human lipid. The methods can include: obtaining whole human milk; separating the milk into a cream portion and a skim portion; processing the cream portion; and pasteurizing the processed cream portion.

Claims

1-5. -5. (canceled)

16-18. -18. (canceled)

21. A method of making a composition comprising a human lipid, the method comprising:

(a) obtaining whole human milk;

(b) separating the milk into a cream portion and a skim portion; and

(c) processing the cream portion, thereby obtaining a composition comprising a human lipid.

6. The method of claim 21, wherein processing the cream portion comprises suspending the cream portion in the water.

7. The method of claim 6, further comprising separating the precipitated protein from the cream portion.

8. The method of claim 21, wherein the cream portion comprises purifying the cream portion.

9. The method of claim 8, wherein the purifying comprises diafiltration.

10. The method of claim 9, further comprising ultrafiltrating.

11. The method of claim 21, further comprising after step (c) adding one or more constituents selected from the group consisting of:

an emulsifier, a preservative, a diluent, and an osmolality modifier.

12. The method of claim 11, wherein the preservative is an antioxidant.

13. The method of claim 12, wherein the antioxidant is selected from the group consisting of:

alpha-tocopherol, vitamin C, a carotenoid, and a retinoid.

14. The method of claim 11, wherein the osmolality modifier comprises glycerin.

15. The method of claim 21, further comprising after step (c), adding one or more constituents selected from the group consisting of:

a vitamin, a mineral, and a carbohydrate.

19. The method of claim 28, wherein the administration is a parenteral administration.

20. The method of claim 28, wherein the administration is part of total parenteral nutritional administration.

22. The method of claim 21, wherein the obtaining step comprises obtaining from about 75 liters to about 2,000 liters of whole human milk.

23. The method of claim 21, further comprising

(i) separating the cream portion obtained in step (b) into a second cream portion and a second skim portion;

and

(ii) in step (c) processing both the cream portion and the second cream portion.

24. The method of claim 21, further comprising filtering water out of the skim portion after step (b).

25. The method of claim 24, wherein processing the cream portion comprises suspending the cream portion in the water.

26. The method of claim 24, further comprising homogenizing the cream portion after step (c).

27. The method of claim 24, further comprising pasteurizing the cream portion after step (c).

28. The method of claim 24, further comprising administering the composition obtained after step (c) to a human subject.

29. The method of claim 28, wherein the subject is a premature infant.

30. The method of claim 28, wherein the subject has a nutritional disease or disorder.

31. The method of claim 28, wherein the administration is an enteral administration.

32. A composition comprising a human lipid fraction from human milk and an emulsifier.

33. The composition of claim 32, wherein the human lipid fraction comprises a pasteurized lipid.

34. The composition of claim 32, wherein the human lipid fraction comprises a human polynunsaturated fatty acid.

35. The composition of claim 34, wherein the fatty acid is an omega-3 fatty acid.

36. The composition of claim 34, wherein the fatty acid is an omega-6 fatty acid.

37. The composition of claim 32, further comprising a constituent selected from the group consisting of:

an antioxidant, a diluent, and an osmolality modifier.

38. The composition of claim 37, wherein the antioxidant is selected from the group consisting of:

alpha-tocopherol, vitamin C, a carotenoid and a retinoid.

39. The composition of claim 38, wherein the osmolality modifier comprises glycerin.

40. The composition of claim 32, further comprising a constituent selected from the group consisting of:

a vitamin, a mineral, and a carbohydrate.

41. A method of treating a subject having a nutritional disease or disorder, the method comprising administering to the subject the composition of claim 32, thereby treating the subject.

42. The method of claim 41, wherein the subject is a human subject.

43. The method of claim 41, wherein the subject is a human infant.