BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY
First Claim
1. A method for delivering a bioactive agent to a human or animal comprising providing a transdermal drug delivery device coupled to the human or animal, the delivery device comprising(a) a source of the bioactive agent,(b) a programmable timing mechanism which implements timing routines, wherein the timing routines are selected to deliver the bioactive agent at a time, rate, sequence and/or cycle that is synchronized with a biological rhythm of the human or animal;
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Accused Products
Abstract
Systems and methods for treating diseases, addictions and disorders in humans and animals involving synchronizing and tailoring the administration of drug compounds with the body'"'"'s natural circadian rhythms, in order to counteract symptoms when they are likely to be at their worst. Automated and pre programmable transdermal drug administration system are used. This system can also utilize a pump or pressurized reservoir, and/or a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with micro-fabricated structures commonly referred to as Micro-needles, or heat, or iontophoresis, sonophoresis, or a wide range of chemical permeation enhancers.
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Citations
22 Claims
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1. A method for delivering a bioactive agent to a human or animal comprising providing a transdermal drug delivery device coupled to the human or animal, the delivery device comprising
(a) a source of the bioactive agent, (b) a programmable timing mechanism which implements timing routines, wherein the timing routines are selected to deliver the bioactive agent at a time, rate, sequence and/or cycle that is synchronized with a biological rhythm of the human or animal; - and
(c) a mechanism for causing the bioactive agent to be delivered transdermally in response to the timing mechanism. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for treating a symptom, condition, and/or disease comprising:
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(a) identifying a drug suitable for treating a particular symptom, condition and/or disease; (b) identifying a biologically superior time for modulating the administration of the drug; (c) programming a time-programmable transdermal drug delivery system with a schedule selected to synchronize with the identified biologically superior time for modulating; and (d) causing the time-programmable transdermal drug delivery system to deliver the active ingredient according to the programmed schedule, wherein the drug delivery system comprises; (i) an interface for coupling to the skin of a host; (ii) a reservoir storing a quantity of an active composition; (iii) a delivery mechanism configured to cause the bioactive agent to be delivered from the reservoir to the skin of the host, wherein the bioactive agent is delivered transdermally to the host, and wherein the quantity of the active composition supplied from the reservoir to the interface is modulated in response to a control signal; and (iv) a timing mechanism coupled to the delivery mechanism and configured to generate the control signal according to a programmed administration schedule.
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8. A programmable transdermal drug delivery device comprising:
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(a) an interface for coupling to the skin of a host; (b) a reservoir storing a quantity of an active composition; (c) a delivery mechanism configured to cause the bioactive agent to be delivered from the reservoir to the skin of the host, wherein the bioactive agent is delivered transdermally to the host, and wherein the quantity of the active composition supplied from the reservoir to the interface is modulated in response to a control signal; and (d) a timing mechanism coupled to the delivery mechanism and configured to generate the control signal according to a programmed administration schedule. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification