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BIOMARKERS FOR MONITORING TREATMENT OF NEUROPSYCHIATRIC DISEASES

  • US 20100280562A1
  • Filed: 04/06/2010
  • Published: 11/04/2010
  • Est. Priority Date: 04/06/2009
  • Status: Abandoned Application
First Claim
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1. A method for identifying biomarkers of neuropsychiatric disease, comprising:

  • (a) calculating a first diagnostic disease score for a subject having said neuropsychiatric disease, wherein said first diagnostic disease score is calculated prior to administration of vagus nerve stimulation to said subject;

    (b) providing numerical values for the levels of one or more analytes in a first biological sample obtained from said subject prior to administration of said vagus nerve stimulation;

    (c) calculating a second diagnostic disease score for said subject after administration of said vagus nerve stimulation;

    (d) providing numerical values for the levels of said one or more analytes in a second biological sample obtained from said subject after administration of said vagus nerve stimulation; and

    (e) identifying one or more analytes as being biomarkers for said neuropsychiatric disease, wherein said one or more analytes are identified as biomarkers if they are differentially expressed between said first and second biological samples, wherein said differential expression of said one or more analytes correlates to a positive or negative change in said subject'"'"'s diagnostic score.

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