PATIENT STATE DETECTION BASED ON SUPPORT VECTOR MACHINE BASED ALGORITHM

• US 20100280574A1
• Filed: 01/26/2010
• Published: 11/04/2010
• Est. Priority Date: 04/30/2009
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Shoeb, Ali H., Denison, Timothy J., Carlson, David L.
• Application Number:
  US12/694,042
• Publication Number:
  US 20100280574A1
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: G06F 18/241 relating to the classification model, e.g. parametric or non-parametric approaches
• CPC Class Codes: G06F 2221/2101 Auditing as a secondary aspect
• CPC Class Codes: G06F 2221/2105 Dual mode as a secondary aspect
• CPC Class Codes: G06N 20/00 Machine learning
• CPC Class Codes: G06N 20/10 using kernel methods, e.g. support vector machines [SVM]
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.

Claims

1. A method comprising:

receiving a signal indicative of a parameter of a patient;

determining a feature vector based on the signal;

applying a support vector machine based algorithm to classify a patient state based on the feature vector, wherein the support vector machine based algorithm defines a classification boundary;

determining a distance between the feature vector and the classification boundary; and

determining an evaluation metric for the patient state based on the distance.

2. The method of claim 1, wherein the feature vector comprises respective values for at least two characteristics of the signal, wherein the characteristics each comprise at least one of an amplitude value or a frequency domain characteristic of the signal.

3. The method of claim 1, wherein the patient state comprises at least one of a seizure state, a mood state, a movement state or a patient posture state.

4. The method of claim 1, wherein the parameter comprises a least one of patient motion or activity, heart rate, respiratory rate, electrodermal activity, thermal activity or muscle activity.

5. The method of claim 1, wherein determining the evaluation metric comprises accessing a data structure that associates a plurality of evaluation metrics with respective distances to the classification boundary.

6. The method of claim 1, wherein the evaluation metric indicates a severity of the patient state.

7. The method of claim 1, further comprising controlling therapy delivery to the patient based on the evaluation metric.

8. The method of claim 7, wherein controlling therapy delivery to the patient comprises selecting at least one therapy parameter value based on the evaluation metric, the method further comprising delivering therapy to the patient based on the selected at least one therapy parameter value.

9. The method of claim 7, wherein the evaluation metric comprises the distance, and wherein controlling delivery of therapy to the patient based on the evaluation metric comprises at least one of deactivating, activating or adjusting therapy delivery to the patient if the evaluation metric is less than or equal to a threshold value.

10. The method of claim 7, wherein the evaluation metric comprises the distance, and wherein controlling delivery of therapy to the patient based on the evaluation metric comprises at least one of deactivating, activating or adjusting therapy delivery to the patient if the evaluation metric is greater than or equal to a threshold value.

11. An implantable medical system comprising:

a sensing module that generates a signal indicative of a parameter of a patient; and

a processor that receives the signal, determines a feature vector based on the signal, applies a support vector machine-based algorithm to classify a patient state based on the feature, wherein the support vector machine-based algorithm defines a classification boundary, and determines an evaluation metric for the patient state based on a distance between the feature vector and the classification boundary.

12. The system of claim 11, further comprising an implantable medical device comprising the processor.

13. The system of claim 12, wherein implantable medical device comprises the sensing module.

14. The system of claim 11, wherein the feature vector comprises respective values for at least two characteristics of the signal, the characteristics each comprising at least one of an amplitude value or a frequency domain characteristic of the signal.

15. The system of claim 11, wherein the patient state comprises at least one of a seizure state, a mood state, a movement state or a patient posture state.

16. The system of claim 11, further comprising a memory that stores a data structure that associates a plurality of evaluation metrics with respective distances to the classification boundary, wherein the processor determines the evaluation metric based on the evaluation metric associated with the distance in the data structure.

17. The system of claim 11, wherein the evaluation metric indicates a severity of the patient state.

18. The system of claim 11, further comprising a therapy module, wherein the processor controls therapy delivery to the patient by the therapy module based on the evaluation metric.

19. The system claim 18, wherein the evaluation metric comprises the distance, and wherein the processor controls the therapy module to at least one of deactivate, activate or adjust therapy delivery by the therapy module if the evaluation metric is less than or equal to a threshold value.

20. The system claim 18, wherein the evaluation metric comprises the distance, and wherein the processor controls the therapy module to at least one of deactivate, activate or adjust therapy delivery by the therapy module if the evaluation metric is greater than or equal to a threshold value.

21. A system comprising:

means for receiving a signal indicative of a parameter of a patient;

means for determining a feature vector based on the signal;

means for applying a support vector machine based algorithm to classify a patient state based on the feature vector, wherein the support vector machine based algorithm defines a classification boundary;

means for determining a distance between the feature vector and the classification boundary; and

means for determining an evaluation metric for the patient state based on the distance.

22. The system of claim 21, further comprising means for controlling therapy delivery to the patient based on the evaluation metric.

23. A computer-readable medium comprising instructions that cause a programmable processor to:

receive a signal indicative of a parameter of a patient;

determine a feature vector based on the signal;

apply a support vector machine based algorithm to classify a patient state based on the feature vector, wherein the support vector machine based algorithm defines a classification boundary;

determine a distance between the feature vector and the classification boundary; and

determine an evaluation metric for the patient state based on the distance.

24. The computer-readable medium of claim 23, further comprising instructions that cause a programmable processor to control therapy delivery to the patient based on the evaluation metric.