BIOINFORMATIC TRANSACTION SCHEME

• US 20100280763A1
• Filed: 07/13/2010
• Published: 11/04/2010
• Est. Priority Date: 11/06/1999
• Status: Abandoned Application

• Current Assignee: Dennis Sunga Fernandez
• Original Assignee: Dennis Sunga Fernandez
• Inventors: Fernandez, Dennis Sunga
• Application Number:
  US12/835,698
• Publication Number:
  US 20100280763A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: G06F 21/6245 Protecting personal data, e.g. for financial or medical purposes
• CPC Class Codes: G06Q 30/02 Marketing; Price estimation or determination; Fundraising
• CPC Class Codes: G06Q 30/0222 During e-commerce, i.e. online transactions
• CPC Class Codes: G06Q 40/08 Insurance
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16B 20/20 Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• CPC Class Codes: G16B 30/00 ICT specially adapted for sequence analysis involving nucleotides or amino acids
• CPC Class Codes: G16B 30/10 Sequence alignment; Homology search
• CPC Class Codes: G16B 50/00 ICT programming tools or database systems specially adapted for bioinformatics
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 70/60 relating to pathologies

Abstract

Secure network transaction system obtains user-authorized genetic term or bioinformatic profile, and transacts online service according to genetically-based user medical or other risk determined therefrom. Insurance policy, promotional offer, or other service may dynamically address genetically-based condition. Bioinformatic data classifies user per personal mask which filters subset of user genetic sequence. Risk profile may be calculated according to actuarial statistics, genetics and/or heredity using non-discriminatory rules specified for users in temporal or jurisdictional groups. User transactions are modifiable according to bioinformatic data representing genetically-based risk increase or decrease. Data is securely processed, modulated, and stored by network server for remote access and transaction using various portable user devices.

Claims

1. A handheld bioinformatic apparatus comprising:

one or more bio sensors for obtaining and processing a DNA and protein sample from the user or other designated person,

a database for storing genomic, proteomic, and phenotypic information about the user or other designated person,

an interface for enabling access to one or more network servers to provide secure transactions, enable effective disease risk assessment, disease diagnosis, and to predict possible responses to medical treatment for the user or designated person,

wherein a predictability value of the user being subject to disease is determinable from the DNA and protein sample obtained from the user or other designated person, a parameter of the disease risk assessment, disease diagnosis and medical treatment response prediction being dependent on the predictability value.

2. The handheld bioinformatic apparatus of claim 1 wherein:

one or more bio sensors monitor nucleic acid concentration by detecting a change of pH resulting from proton release when the amplification of a user or designated person'"'"'s DNA proceeds beyond a threshold number of PCR cycles, thus overcoming the buffering capacity of the bio sensor'"'"'s sample buffer, thereby enabling the generation of an electrical output signal in response to change of pH and its detection via an electrical output signal.

3. The handheld bioinformatic apparatus of claim 1 wherein:

one or more bio sensors comprise an ion-sensitive field effect transistor (ISFET) having a sensing surface exposed to the sample and arranged to generate an electrical output signal in response to change of pH at said transistor surface and means for detecting an electrical output signal from said ISFET.

4. The handheld bioinformatic apparatus of claim 1 further comprising:

a microfluidic device in which one or more chambers or channels to receive the DNA and protein sample are in or on a substrate chosen from the group of silicon, glass, polymers or ceramics, and one or more pH-sensitive ISFETS are arranged for monitoring of nucleic acid amplification in said chambers or channels.

5. The handheld bioinformatic apparatus of claim 1 wherein:

the DNA and protein samples obtained from the users or other designated persons comprise a set of single nucleotide polymorphisms (SNPs) and target proteins associated with heart disease, thereby enabling effective heart disease diagnosis and prediction of possible responses to medical treatment for heart disease.