Spiral, Microchanneled Chromatographic Column And Detection Systems

• US 20100281948A1
• Filed: 05/07/2009
• Published: 11/11/2010
• Est. Priority Date: 05/07/2009
• Status: Active Grant

• Current Assignee: Southwest Research Institute
• Original Assignee: Southwest Research Institute
• Inventors: Wellinghoff, Stephen Thomas, Coulter, Kent Edward
• Granted Patent: US 8,636,957 B2
• Time in Patent Office: Days
• US Class Current: 73/23.37
• CPC Class Codes: B32B 37/02 characterised by a sequence of laminating steps, e.g. by adding new layers at consecutive laminating stations
• CPC Class Codes: G01N 30/463 for multidimensional chromatography
• CPC Class Codes: G01N 30/6052 body
• CPC Class Codes: G01N 30/6095 Micromachined or nanomachined, e.g. micro- or nanosize
• CPC Class Codes: G01N 30/7206 interfaced to gas chromatograph interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04

Abstract

The present disclosure relates to a spirally wrapped chromatographic structure, a system incorporating such structure and a method of providing such structure. The structure may include an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in the first surface. The structure may also include a support layer having a first surface and a second surface, the first surface of the support layer disposed on the second surface of the absorber layer, wherein the absorber layer and the support layer comprise a spiral configuration such that at least a portion of the first surface of the absorber layer contacts at least a portion of the second surface of the support layer.

Claims

1. A spirally wrapped chromatographic structure, comprising:

an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface; and

a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer comprise a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer.

2. The structure of claim 1, wherein said structure comprises a chromatographic column and said absorber layer comprises a stationary layer.

3. The structure of claim 1, wherein said channels are 0.1 μ

m to 10,000 μ

m in thickness and/or in depth.

4. The structure of claim 1, wherein said support layer comprises an electrically resistive layer.

5. The structure of claim 1, wherein said absorber layer comprises at least two material compositions, wherein the material compositions vary with respect to McReynold'"'"'s values along the axial axis or radius of said structure.

6. The structure of claim 1, wherein said absorber layer comprises a fluoroalcohol polycarbosilane and/or fluoroalcohol polycarbosiloxane.

7. The structure of claim 1 wherein said absorber layer comprises:

8. The structure of claim 1 wherein the absorber layer comprises:

9. The structure of claim 1, wherein said absorber layer comprises AgF.

10. The structure of claim 1, wherein said absorber layer comprises metal organic frameworks.

11. A system for chromatographic analysis, comprising:

at least one chromatography column, wherein said chromatography column comprises a spirally wrapped structure including an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface and a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer are rolled into a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer; and

a detector.

12. The system of claim 11, further comprising a second chromatography column including a second absorber layer, wherein said first absorber layer is different that said second absorber layer.

13. The system of claim 11 further comprising a preconcentrator containing a second spirally wrapped structure including an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface and a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer are rolled into a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer.

14. The system of claim 11 further comprising a water scrubber containing a second spirally wrapped structure including an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface and a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer are rolled into a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer.

15. The system of claim 11, further comprising a thermal or pressure modulator containing a second spirally wrapped structure including an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface and a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer are rolled into a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer.

16. The system of claim 11, further comprising a post-concentrator containing a second spirally wrapped structure including an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in said first surface and a support layer having a first surface and a second surface, the first surface of the support layer disposed on said second surface of said absorber layer, wherein said absorber layer and said support layer are rolled into a spiral configuration such that at least a portion of said first surface of said absorber layer contacts at least a portion of said second surface of said support layer.

17. The system of claim 11, wherein said detector is a mass spectrometer.

18. The system of claim 17, wherein said detector is a multi-bounce time of flight mass spectrometer.

19. A method of forming a spirally wrapped chromatography structure, comprising:

providing a substrate including one or more channels defined on a first surface;

coating said substrate with a release layer;

disposing an absorber layer over said release layer, having a first surface contacting said release layer and a second surface;

disposing a support layer on said second surface of said absorber layer; and

removing said substrate.

20. A method of providing a spirally wrapped chromatography structure, comprising:

(a) coating an embossed film material with a release layer;

(b) coating on said release layer an electrically resistant material;

(c) coating said electrically resistant material with absorber material;

(d) wrapping the product of (c) and forming a spirally wrapped chromatographic structure comprising a plurality of absorber layers including one or more channels therein which overlap one another in a continuous manner wherein the channels extend continuously around an axis.