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METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO ENABLE RAPID RELIEF OF MIGRAINE WHILE MINIMIZING SIDE EFFECT PROFILE

  • US 20100284940A1
  • Filed: 07/19/2010
  • Published: 11/11/2010
  • Est. Priority Date: 02/11/2007
  • Status: Active Grant
First Claim
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1. A method comprising:

  • administering a total dose of dihydroergotamine, or a complex, chelate, salt, hydrate, polymorph, or ion pair thereof to a human suffering from migraine;

    wherein the dihydroergotamine, or a complex, chelate, salt, hydrate, polymorph, or ion pair thereof is administered at such a rate that a mean peak plasma concentration (Cmax) of dihydroergotamine thereof is less than 60,000 pg/ml;

    a mean time to Cmax (Tmax) of dihydroergotamine is less than 20 minutes; and

    wherein the total dose of dihydroergotamine, or a complex, chelate, salt, hydrate, polymorph, or ion pair thereof ranges from 0.1 to 10 mg per migraine.

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