COENZYME Q10-CONTAINING WATER-SOLUBLE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF

• US 20100284983A1
• Filed: 06/14/2006
• Published: 11/11/2010
• Est. Priority Date: 06/15/2005
• Status: Active Grant

• Current Assignee: Kaneka Corporation
• Original Assignee: Kaneka Corporation
• Inventors: Ikehara, Toshinori, Kishida, Hideyuki
• Granted Patent: US 8,388,950 B2
• Time in Patent Office: Days
• US Class Current: 424/94.1
• CPC Class Codes: A23K 20/174 Vitamins
• CPC Class Codes: A23L 29/10 containing emulsifiers
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 8/355 Quinones
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A coenzyme Q₁₀-containing water soluble composition comprises coenzyme Q₁₀, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q₁₀-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q₁₀-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q₁₀-containing water soluble composition or the above-mentioned coenzyme Q₁₀-containing water-soluble dry powder. The coenzyme Q₁₀-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.

Claims

1. A coenzyme Q₁₀-containing water soluble composition

which comprises coenzyme Q₁₀, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester, and an aqueous phase component.

2. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the hydrophilic polyglycerol fatty acid ester is a decaglycerol mono-saturated fatty acid ester constituted of a fatty acid residue containing 12 or more carbon atoms.

3. The coenzyme Q₁₀-containing water soluble composition according to claim 2,

wherein the saturated fatty acid ester is at least one species selected from the group consisting of a laurate ester, a myristate ester and a palmitate ester.

4. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the lipophilic sucrose fatty acid ester is an ester composed of a higher fatty acid and acetic acid.

5. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

which comprises 0.01 to 40% by weight of coenzyme Q₁₀ in the whole water soluble composition.

6. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the content of the hydrophilic polyglycerol fatty acid ester is 1 to 500 parts by weight to 100 parts by weight of coenzyme Q₁₀.

7. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the content of the lipophilic sucrose fatty acid ester is 1 to 200 parts by weight to 100 parts by weight of coenzyme Q₁₀.

8. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the median size of emulsion particles in the water soluble composition is not larger than 100 nm.

9. The coenzyme Q₁₀-containing water soluble composition according to claim 1,

wherein the aqueous phase component is a polyhydric alcohol and/or water.

10. A coenzyme Q₁₀-containing water-soluble dry powder

which is obtained by drying the coenzyme Q₁₀-containing water soluble composition according to claim 1.

11. A process for producing the coenzyme Q₁₀-containing water soluble composition according to claim 1,

which comprises making the median size of emulsion particles in the water soluble composition to be not larger than 100 nm by applying homogenization pressure of not less than 50 MPa.

12. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food

which is obtained by using the coenzyme Q₁₀-containing water soluble composition according to claim 1 or which is obtained by using a coenzyme Q₁₀-containing water-soluble dry powder which is obtained by drying the coenzyme Q₁₀-containing water soluble composition according to claim 1.