Ophthalmic Compositions with Hyaluronic Acid

• US 20100286010A1
• Filed: 07/21/2010
• Published: 11/11/2010
• Est. Priority Date: 09/03/2008
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Barniak, Vicki, Venkatesh, Srini, Xia, Erning, Burke, Susan E.
• Application Number:
  US12/840,796
• Publication Number:
  US 20100286010A1
• Time in Patent Office: Days
• US Class Current: 510/112
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61K 9/5084 Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs tablets containing such a mixture A61K9/2077
• CPC Class Codes: C11D 1/88 Ampholytes; Electroneutral compounds C11D1/002, C11D1/004, C11D1/008 take precedence
• CPC Class Codes: C11D 1/92 Sulfobetaines ; Sulfitobetaines
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/222 Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
• CPC Class Codes: C11D 3/26 containing nitrogen C11D3/162, C11D3/164, C11D3/166, C11D3/168 take precedence
• CPC Class Codes: C11D 3/37 Polymers polymeric surface-active agents C11D1/008; polysaccharides C11D3/222
• CPC Class Codes: C11D 3/3723 Polyamines or polyalkyleneimines
• CPC Class Codes: C11D 3/3773 in liquid compositions
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

An aqueous solution for cleaning and disinfecting a contact lens comprising 0.5 ppm to 5 ppm of 1,1′-hexamethylene-bis[5-(2-ethylhexyl)biguanide;

• • 0.5 ppm to 3 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride;
  • 0.005 wt. % to 0.04 wt. % hyaluronic acid;
  • a boric acid/borate buffer; and
  • a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof.

Claims

1. An aqueous contact lens care solution composition comprising:

0.5 ppm to 5 ppm of 1,1′

-hexamethylene-bis[5-(2-ethylhexyl)biguanide;

0.5 ppm to 3 ppm α

-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω

-tris(2-hydroxyethyl)ammonium chloride;

0.005 wt. % to 0.04 wt. % hyaluronic acid;

a boric acid/borate buffer; and

a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof.

2. The contact lens solution of claim 1 wherein the nonionic surfactant is poloxamine with an HLB value from 13 to 28.

3. The contact lens solution of claim 1 wherein the 1,1′

-hexamethylene-bis[5-(2-ethylhexyl)biguanide is present from 0.5 ppm to 2 ppm.

4. The contact lens solution of claim 1 0.01 wt. % to 0.6 wt. % of a sulfobetaine of general formula I

5. The contact lens solution of claim 4 wherein R¹ is a straight, saturated C₁₀alkyl.

6. The contact lens solution of claim 1 further comprising propylene glycol, hydroxypropyl guar or myristamidopropyl dimethylamine.

7. The contact lens solution of claim 1 further comprising hydroxypropylmethyl cellulose.

8. The contact lens solution of claim 1 further comprising citrate, citric acid or a mixture thereof.

9. The contact lens solution of claim 1 wherein the hyaluronic acid is present from 0.005 wt. % to 0.02 wt. % hyaluronic acid;

10. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in the ophthalmic composition for at least two hours, the composition comprising:

0.5 ppm to 5 ppm of 1,1′

-hexamethylene-bis[5-(2-ethylhexyl)biguanide;

0.5 ppm to 3 ppm α

-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω

-tris(2-hydroxyethyl)ammonium chloride;

0.005 wt. % to 0.04 wt. % hyaluronic acid;

a boric acid/borate buffer; and

a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof.

11. The method of claim 10 wherein the composition further comprises citrate, citric acid or a mixture thereof.