Finger-1 Peptide Analogs of the TGF-Beta Superfamily
First Claim
Patent Images
1. An isolated polypeptide consisting of an active fragment of at least 8 consecutive amino acid residues of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
11;
SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, wherein the polypeptide has the ability to bind to and stabilize a TGF-β
superfamily member protein in solution.
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Abstract
Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
10 Citations
12 Claims
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1. An isolated polypeptide consisting of an active fragment of at least 8 consecutive amino acid residues of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
11;
SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, wherein the polypeptide has the ability to bind to and stabilize a TGF-β
superfamily member protein in solution. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12)
- 1, SEQ ID NO;
-
2. An isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
11;
SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23. - View Dependent Claims (3)
- 1, SEQ ID NO;
Specification
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Current AssigneeWyeth LLC (Pfizer Inc.)
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Original AssigneeWyeth LLC (Pfizer Inc.)
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InventorsZhang, Jimin, Yaworsky, Paul John, Olland, Stephane H., Shen, Emily Sheng-ming, Brown, Christopher Todd, Lu, Zhijian, Liu, Wei
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Application NumberUS12/817,718Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/21.3CPC Class CodesA61K 38/00 Medicinal preparations cont...A61P 17/02 for treating wounds, ulcers...C07K 1/22 Affinity chromatography or ...C07K 14/475 Growth factors; Growth regu...C07K 14/495 Transforming growth factor ...C07K 14/51 Bone morphogenetic factor; ...
