Method and composition to improve absorption of therapeutic agents
First Claim
Patent Images
1. A blend for forming into a pharmaceutical tablet comprising crystals of a medicinally active ingredient having a particle size less than about 40 μ
- m and a dissolution aid, wherein said blend has been sufficiently milled to substantially coat said crystals with said dissolution aid, whereby the dissolution rate of said medicinally active ingredient when formed into a tablet is enhanced compared to the dissolution rate of said active ingredient in a tablet without such milling.
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Abstract
A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient.
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Citations
17 Claims
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1. A blend for forming into a pharmaceutical tablet comprising crystals of a medicinally active ingredient having a particle size less than about 40 μ
- m and a dissolution aid, wherein said blend has been sufficiently milled to substantially coat said crystals with said dissolution aid, whereby the dissolution rate of said medicinally active ingredient when formed into a tablet is enhanced compared to the dissolution rate of said active ingredient in a tablet without such milling.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for manufacturing a delivery vehicle for a medicinally active ingredient comprising the steps of:
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a. Preparing a pre-blend of crystals of said medicinally active ingredient and a dissolution aid; b. Milling said pre-blend for a time sufficient to establish a particle size of said crystals of not more than about 40 μ
m and to substantially coat said crystals with said dissolution aid to form a blend; andc. Compressing said blend to form said delivery vehicle. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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Specification